Evidence map›Paper›PMID 25908996›Full record

ArticleJournal of AIDS & clinical research2015

Response to Pneumococcal Polysaccharide Vaccination in HIV-Positive Individuals on Long Term Highly Active Antiretroviral Therapy.

Anita S Iyer, David J Leggat, Jennifer A Ohtola, Joan M Duggan, Claudiu A Georgescu, Adeeb A Al Rizaiza, Sadik A Khuder, Noor M Khaskhely, Julie Westerink

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of AIDS & clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
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  6. Creating a Reliable, Cost-Effective ELISA Simulation.The American biology teacher · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Anita S IyerDepartment of Medicine, University of Toledo, USA.
David J LeggatDepartment of Medicine, University of Toledo, USA.
Jennifer A OhtolaDepartment of Medicine, University of Toledo, USA.
Joan M DugganDepartment of Medicine, University of Toledo, USA ; Department of Medical Microbiology and Immunology, University of Toledo, USA ; Department of Internal Medicine, University of Toledo, USA ; Department of Pathology, University of Toledo, USA ; Department of Physiology, University of Toledo, USA ; Department of Pharmacology, University of Toledo, USA ; Department of Metabolism and Cardiovascular Science, University of Toledo, USA.
Claudiu A GeorgescuDepartment of Medicine, University of Toledo, USA.
Adeeb A Al RizaizaDepartment of Medicine, University of Toledo, USA.
Sadik A KhuderDepartment of Medicine, University of Toledo, USA ; Department of Public Health, University of Toledo, USA.
Noor M KhaskhelyDepartment of Medicine, University of Toledo, USA.
Julie WesterinkDepartment of Medicine, University of Toledo, USA ; Department of Medical Microbiology and Immunology, University of Toledo, USA ; Department of Internal Medicine, University of Toledo, USA ; Department of Pathology, University of Toledo, USA.
University of Toledo · US

Funding

Immune Response to Pneumococcal Vaccination in HIV Infected AdultsR01AI081558 · NIAID · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WESTERINK, M.A. JULIA · 2010 to 2013
$1.5M
NIAID NIH HHS R01 AI081558
6 · The paper itself

Abstract

BACKGROUND AND

objectivesDESIGN AND

methodsWe assessed antibody levels, opsonophagocytic activity and phenotype of pneumococcal polysaccharide (PPS) specific-B cells post-revaccination in long term HAART cohorts stratified according to CD4 count as group A (CD4>200) and group B (CD4<200). Anti-PPS IgG, IgM and functional antibody response against vaccine serotypes 14 and 23F were measured by ELISA and opsonophagocytic assay followed by phenotypic analysis of PPS14 and 23F-specific B cells using fluorescently labeled PPS.

resultsSignificant increases in total and functional antibody titers were noted in groups A and B post-vaccination concomitant with significant rise in PPS-specific IgM memory B cells, a critical B cell subset required for protection against PPS although the overall response remained significantly diminished compared to HIV-negative volunteers.

conclusionComparable increases in opsonophagocytic titers between study groups A and B concomitant with a comparable rise in PPS-specific IgM memory B cells indicate revaccination to be beneficial regardless of the degree of CD4 T cell reconstitution. These findings emphasize the importance of defining effective vaccination practices amongst high-risk individuals.

Indexed as

B cellsHAARTHIVImmune-responsePneumococcal-polysaccharidesPPV23-vaccinationStreptococcus pneumoniae

Identifiers

PMID25908996
PMCPMC4405245
OpenAlexW2168866287

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.