Evidence map›Paper›PMID 25908935›Full record

ArticleAIDS research and therapy2015

Guidelines for antiretroviral therapy in HIV-1 infected adults and adolescents 2014, Thailand.

Weerawat Manosuthi, Sumet Ongwandee, Sorakij Bhakeecheep, Manoon Leechawengwongs, Kiat Ruxrungtham, Praphan Phanuphak, Narin Hiransuthikul, Winai Ratanasuwan, Ploenchan Chetchotisakd, Woraphot Tantisiriwat and 5 more

Open access · goldAbstract read
In one paragraph

Article in AIDS research and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Weerawat ManosuthiDepartment of Medicine, Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Tiwanon Road, Nonthaburi, 11000 Thailand.
Sumet OngwandeeBureau of AIDS, TB, and STIs, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
Sorakij BhakeecheepNational Health Security Office, Bangkok, Thailand.
Manoon LeechawengwongsThai AIDS Society, Bangkok, Thailand.
Kiat RuxrungthamDepartment of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand ; HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Praphan PhanuphakDepartment of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand ; HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Narin HiransuthikulDepartment of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Winai RatanasuwanFaculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Ploenchan ChetchotisakdFaculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Woraphot TantisiriwatDepartment of Preventive Medicine, Faculty of Medicine Srinakharinwirot University, Nakornnayok, Thailand.
Sasisopin KiertiburanakulFaculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Anchalee AvihingsanonHIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Akechittra SukkulThailand Ministry of Public Health-U.S. CDC Collaboration (TUC), Nonthaburi, Thailand.
Thanomsak AnekthananonFaculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Adults and Adolescents Committee of the Thai National HIV Guidelines Working Group
Chulalongkorn University · THMinistry of Public Health · THMahidol University · THHIV Netherlands Australia Thailand Research Collaboration · THKhon Kaen University · THSiriraj Hospital · THSocial Security Office (Thailand) · THSrinakharinwirot University · THThai Red Cross Society · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New evidence has emerged regarding when to commence antiretroviral therapy (ART), optimal treatment regimens, management of HIV co-infection with opportunistic infections, and management of ART failure. The 2014 guidelines were developed by the collaborations of the Department of Disease Control, Ministry of Public Health (MOPH) and the Thai AIDS Society (TAS). One of the major changes in the guidelines included recommending to initiating ART irrespective of CD4 cell count. However, it is with an emphasis that commencing HAART at CD4 cell count above 500 cell/mm(3) is for public health, in term of preventing HIV transmission and personal benefit. In tuberculosis co-infected patients with CD4 cell counts ≤50 cells/mm(3) or with CD4 cell counts >50 cells/mm(3) who have severe clinical disease, ART should be initiated within 2 weeks of starting tuberculosis treatment. The preferred initial ART regimen in treatment naïve patients is efavirenz combined with tenofovir and emtricitabine or lamivudine. Plasma HIV viral load assessment should be done twice a year until achieving undetectable results; and will then be monitored once a year. CD4 cell count should be monitored every 6 months until CD4 cell count ≥350 cells/mm(3) and with plasma HIV viral load <50 copies/mL; then it should be monitored once a year afterward. HIV drug resistance genotypic test is indicated when plasma HIV viral load >1,000 copies/mL while on ART. Ritonavir-boosted lopinavir or atazanavir in combination with optimized two nucleoside-analogue reverse transcriptase inhibitors is recommended after initial ART regimen failure. Long-term ART-related safety monitoring has also been included in the guidelines.

Identifiers

PMID25908935
PMCPMC4407333
OpenAlexW2096150279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.