ReviewThe EMBO journal2015
Forward engineering neuronal diversity using direct reprogramming.
Review in The EMBO journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- To recruit or to graft? Comparing the recruitment of resident non-neuronal cells by lineage reprogramming with engraftment of stem cell-derived neurons for neuronal replacement therapies.Frontiers in neuroscience · 2025Review
- Review
- Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Molecular Mechanisms Underlying Ascl1-Mediated Astrocyte-to-Neuron Conversion.Stem cell reports · 2021Article
- Human pluripotent stem cell-derived models and drug screening in CNS precision medicine.Annals of the New York Academy of Sciences · 2020Review
- Probing disrupted neurodevelopment in autism using human stem cell-derived neurons and organoids: An outlook into future diagnostics and drug development.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains.Frontiers in neuroscience · 2019Review
- Development and validation of an in vitro model system to study peripheral sensory neuron development and injury.Scientific reports · 2018Article
- Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries.Nature biotechnology · 2017Article
- Deep intronic mutations and human disease.Human genetics · 2017Review
- Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.Cell reports · 2017Article
- Computational methods for direct cell conversion.Cell cycle (Georgetown, Tex.) · 2016Review
- Development of regional specificity of spinal and medullary dorsal horn neurons.World journal of biological chemistry · 2016Review
- Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation.NPJ aging and mechanisms of disease · 2016Review
- RNAseq analysis for the diagnosis of muscular dystrophy.Annals of clinical and translational neurology · 2016Article
- Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases.Trends in molecular medicine · 2015Review
- Probing disorders of the nervous system using reprogramming approaches.The EMBO journal · 2015Review
- Development of stem cell-based therapy for Parkinson's disease.Translational neurodegeneration · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nervous system is comprised of a vast diversity of distinct neural cell types. Differences between neuronal subtypes drive the assembly of neuronal circuits and underlie the subtype specificity of many neurological diseases. Yet, because neurons are irreversibly post-mitotic and not readily available from patients, it has not been feasible to study specific subtypes of human neurons in larger numbers. A powerful means to study neuronal diversity and neurological disease is to establish methods to produce desired neuronal subtypes in vitro. Traditionally this has been accomplished by treating pluripotent or neural stem cells with growth factors and morphogens that recapitulate exogenous developmental signals. These approaches often require extended periods of culture, which can limit their utility. However, more recently, it has become possible to produce neurons directly from fibroblasts using transcription factors and/or microRNAs. This technique referred to as direct reprogramming or transdifferentiation has proven to be a rapid, robust, and reproducible method to generate mature neurons of many different subtypes from multiple cell sources. Here, we highlight recent advances in generating neurons of specific subtypes using direct reprogramming and outline various scenarios in which induced neurons may be applied to studies of neuronal function and neurological disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.