Evidence map›Paper›PMID 25908514›Full record

ArticleBioorganic & medicinal chemistry letters2015

Identification of lead compounds for (99m)Tc and (18)F GPR91 radiotracers.

Jeffrey Klenc, Malgorzata Lipowska, Andrew T Taylor

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jeffrey KlencDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA. Electronic address: jeff.klenc@gmail.com.
Malgorzata LipowskaDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Andrew T TaylorDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Emory University · US

Funding

Development of Tc-99m Renal Tubular TracersR37DK038842 · NIDDK · EMORY UNIVERSITY · PI TAYLOR, ANDREW THOMPSON · 2009 to 2017
$3.4M
DEVELOPMENT OF TC-99M RENAL TUBULAR AGENTSR01DK038842 · NIDDK · EMORY UNIVERSITY · PI TAYLOR, ANDREW THOMPSON · 1986 to 2008
$2.6M
NIDDK NIH HHS R01 DK038842NIDDK NIH HHS R37 DK038842NIDDK NIH HHS R37 DK38842
6 · The paper itself

Abstract

To develop the first radiotracer targeting GPR91, a cell membrane-bound receptor that modulates the cellular response to hyperglycemia and hypoxia, we designed and prepared a small series of compounds based on a published series of 1,8-naphthyridines with high affinity to GPR91. Our approach provides a mechanism to incorporate radioactive atoms ((99m)Tc and (18)F) into the GPR91 pharmacophore as the final synthetic step. Pharmacological assays confirmed lead compounds for (99m)Tc and (18)F GPR91 radiotracers within the series.

Indexed as

AnimalsDrug DiscoveryFluorineFluorine RadioisotopesKidneyMolecular StructureNaphthyridinesRadioactive TracersRatsReceptors, G-Protein-CoupledTechnetiumFluorineFluorine RadioisotopesNaphthyridinesRadioactive TracersReceptors, G-Protein-CoupledTechnetiumDiabetesGPR91HyperglycemiaHypoxiaLead identificationRadiotracer

Identifiers

PMID25908514
PMCPMC4433761
OpenAlexW2018005218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.