Trial reportStroke2015
Patterns of poststroke brain damage that predict speech production errors in apraxia of speech and aphasia dissociate.
Trial report in Stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Mapping the neural patterns of verbal repetition: an activation likelihood estimation meta-analysis.Brain structure & function · 2026Pooled it
- The use of standardised short-term and working memory tests in aphasia research: a systematic review.Neuropsychological rehabilitation · 2018Pooled it
- Targeting auditory verbal hallucinations in schizophrenia: effective connectivity changes induced by low-frequency rTMS.Translational psychiatry · 2024Trial
- A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech.Nature communications · 2021Trial
- Meaning for reading pseudowords: errors reveal semantic influences on pseudoword reading after stroke.bioRxiv : the preprint server for biology · 2026Article
- Diagnosing Apraxia of Speech in Children and Adults When There Is No Gold Standard: A Scoping Review About the Diagnostic Process.American journal of speech-language pathology · 2026Article
- LeCoder: A large-scale automated coder for coding errors in word-production tasks.Behavior research methods · 2026Article
- Speech sequencing in the human precentral gyrus.Nature human behaviour · 2025Article
- Effective neural connectivity deficits during speech auditory feedback processing in post-stroke aphasia: An fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Functional Disconnections of the Pre-Supplementary Motor Area in Patients With Post-Stroke Aphasia and Their Associations With Neurotransmitters.CNS neuroscience & therapeutics · 2025Article
- Refined Operational Definitions for the Apraxia of Speech Rating Scale.American journal of speech-language pathology · 2025Article
- A Novel Candidate Neuromarker of Central Motor Dysfunction in Childhood Apraxia of Speech.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Semantic language decoding across participants and stimulus modalities.Current biology : CB · 2025Article
- Decoding speech intent from non-frontal cortical areas.Journal of neural engineering · 2025Article
- Role for Left Dorsomedial Prefrontal Cortex in Self-Generated, but not Externally Cued, Language Production.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Partial least squares multimodal analysis of brain network correlates of language deficits in aphasia.Brain communications · 2025Article
- The speech neuroprosthesis.Nature reviews. Neuroscience · 2024Review
- Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum.Brain : a journal of neurology · 2024Article
- Apraxia of speech due to the left postcentral gyrus lesion.Clinical case reports · 2024Article
- Dissociating reading and auditory comprehension in persons with aphasia.Brain communications · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeAcquired apraxia of speech (AOS) is a motor speech disorder caused by brain damage. AOS often co-occurs with aphasia, a language disorder in which patients may also demonstrate speech production errors. The overlap of speech production deficits in both disorders has raised questions on whether AOS emerges from a unique pattern of brain damage or as a subelement of the aphasic syndrome. The purpose of this study was to determine whether speech production errors in AOS and aphasia are associated with distinctive patterns of brain injury.
methodsForty-three patients with history of a single left-hemisphere stroke underwent comprehensive speech and language testing. The AOS Rating Scale was used to rate speech errors specific to AOS versus speech errors that can also be associated with both AOS and aphasia. Localized brain damage was identified using structural magnetic resonance imaging, and voxel-based lesion-impairment mapping was used to evaluate the relationship between speech errors specific to AOS, those that can occur in AOS or aphasia, and brain damage.
resultsThe pattern of brain damage associated with AOS was most strongly associated with damage to cortical motor regions, with additional involvement of somatosensory areas. Speech production deficits that could be attributed to AOS or aphasia were associated with damage to the temporal lobe and the inferior precentral frontal regions.
conclusionsAOS likely occurs in conjunction with aphasia because of the proximity of the brain areas supporting speech and language, but the neurobiological substrate for each disorder differs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.