ArticleNeuropharmacology2015
Dopaminergic and cholinergic modulation of striatal tyrosine hydroxylase interneurons.
Article in Neuropharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- 20 Hz tACS engages striatal THINs to enhance β-band synchrony and motor drive.Frontiers in neuroscience · 2026Article
- Tyrosine Hydroxylase-Positive Nucleus Accumbens Neurons Influence Delay Discounting in a Mouse T-Maze Task.eNeuro · 2024Article
- Investigating cell-specific effects of FMRP deficiency on spiny projection neurons in a mouse model of Fragile X syndrome.Frontiers in cellular neuroscience · 2023Article
- Cholinergic control of striatal GABAergic microcircuits.Cell reports · 2022Article
- Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation.International journal of molecular sciences · 2022Article
- Article
- Nicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism.Frontiers in synaptic neuroscience · 2022Article
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Striatal cholinergic transmission. Focus on nicotinic receptors' influence in striatal circuits.The European journal of neuroscience · 2021Review
- Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.Nature communications · 2020Article
- Neural substrates of habit.Journal of neuroscience research · 2020Review
- Loss of striatal tyrosine-hydroxylase interneurons impairs instrumental goal-directed behavior.The European journal of neuroscience · 2019Article
- Excitatory extrinsic afferents to striatal interneurons and interactions with striatal microcircuitry.The European journal of neuroscience · 2019Review
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Identification and Characterization of a Novel Spontaneously Active Bursty GABAergic Interneuron in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Striatal cholinergic interneurons and Parkinson's disease.The European journal of neuroscience · 2018Review
- Heterogeneity and Diversity of Striatal GABAergic Interneurons: Update 2018.Frontiers in neuroanatomy · 2018Article
- Review
- Differential processing of thalamic information via distinct striatal interneuron circuits.Nature communications · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The recent electrophysiological characterization of TH-expressing GABAergic interneurons (THINs) in the neostriatum revealed an unexpected degree of diversity of interneurons in this brain area (Ibáñez-Sandoval et al., 2010, Unal et al., 2011, 2015). Despite being relatively few in number, THINs may play a significant role in transmitting and distributing extra- and intrastriatal neuromodulatory signals in the striatal circuitry. Here we investigated the dopaminergic and cholinergic regulation of THINs in vitro. We found that the dominant effect of dopamine was a dramatic enhancement of the ability of THINs to generate long-lasting depolarizing plateau potentials (PPs). Interestingly, the same effect could also be elicited by amphetamine-induced release of endogenous dopamine suggesting that THINs may exhibit similar responses to changes in extracellular dopamine concentration in vivo. The enhancement of PPs in THINs is perhaps the most pronounced effect of dopamine on the intrinsic excitability of neostriatal neurons described to date. Further, we demonstrate that all subtypes of THINSs tested also express nicotinic cholinergic receptors. All THIS responded, albeit differentially, with depolarization, PPs and spiking to brief application of nicotinic agonists. Powerful modulation of the nonlinear integrative properties of THINs by dopamine and the direct depolarization of these neurons by acetylcholine may play important roles in mediating the effects of these neuromodulators in the neostriatum with potentially important implications for understanding the mechanisms of neuropsychiatric disorders affecting the basal ganglia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.