ArticleJournal of pineal research2015
Melatonin modulates the fetal cardiovascular defense response to acute hypoxia.
Article in Journal of pineal research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Still in the dark? Cardiovascular risks of perinatal melatonin.Pediatric research · 2026Article
- Prenatal Melatonin Modulates Cardiovascular Function and Oxidative Stress in Guinea Pig Neonates Under Normoxic and Hypoxic Gestation.Antioxidants (Basel, Switzerland) · 2026Article
- Antenatal melatonin for cardiovascular deficits in fetal growth restriction.The Journal of physiology · 2026Article
- Antioxidants: powering the fight against fetal hypoxia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Past and Present of the Antioxidant Studies in Chile: A Bibliometric Study from 2000 to 2024.Antioxidants (Basel, Switzerland) · 2025Article
- Effects of Melatonin on Exercise-Induced Oxidative Stress in Adults with Obesity Undergoing a Multidisciplinary Body Weight Reduction Program.Journal of clinical medicine · 2024Article
- Hypotensive effects of melatonin in rats: Focus on the model, measurement, application, and main mechanisms.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: role of ROS/ERK1/2.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Prenatal Hypoxia Affects Foetal Cardiovascular Regulatory Mechanisms in a Sex- and Circadian-Dependent Manner: A Review.International journal of molecular sciences · 2022Review
- Breath of Life: Heart Disease Link to Developmental Hypoxia.Circulation · 2021Article
- Supplementary Tryptophan Fed to Sows Prior to and after Farrowing to Improve Piglet Growth and Survival.Animals : an open access journal from MDPI · 2021Article
- Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction.Science advances · 2020Article
- Identification of long noncoding RNAs involved in adaptability to chronic hypoxic by whole transcriptome sequencing.3 Biotech · 2020Article
- Getting an Early Start in Understanding Perinatal Asphyxia Impact on the Cardiovascular System.Frontiers in pediatrics · 2020Review
- Maternal and fetal cardiometabolic recovery following ultrasound-guided high-intensity focused ultrasound placental vascular occlusion.Journal of the Royal Society, Interface · 2019Article
- Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs.Frontiers in endocrinology · 2019Article
- Melatonin Increases Fetal Weight in Wild-Type Mice but Not in Mouse Models of Fetal Growth Restriction.Frontiers in physiology · 2018Article
- Acute hypoxia-reoxygenation and vascular oxygen sensing in the chicken embryo.Physiological reports · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction. However, the effects of melatonin on the fetal defense to acute hypoxia, such as that which may occur during labor, remain unknown. This translational study tested the hypothesis, in vivo, that melatonin modulates the fetal cardiometabolic defense responses to acute hypoxia in chronically instrumented late gestation fetal sheep via alterations in fetal nitric oxide (NO) bioavailability. Under anesthesia, 6 fetal sheep at 0.85 gestation were instrumented with vascular catheters and a Transonic flow probe around a femoral artery. Five days later, fetuses were exposed to acute hypoxia with or without melatonin treatment. Fetal blood was taken to determine blood gas and metabolic status and plasma catecholamine concentrations. Hypoxia during melatonin treatment was repeated during in vivo NO blockade with the NO clamp. This technique permits blockade of de novo synthesis of NO while compensating for the tonic production of the gas, thereby maintaining basal cardiovascular function. Melatonin suppressed the redistribution of blood flow away from peripheral circulations and the glycemic and plasma catecholamine responses to acute hypoxia. These are important components of the fetal brain sparing response to acute hypoxia. The effects of melatonin involved NO-dependent mechanisms as the responses were reverted by fetal treatment with the NO clamp. Melatonin modulates the in vivo fetal cardiometabolic responses to acute hypoxia by increasing NO bioavailability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.