Evidence map›Paper›PMID 25908073›Full record

ReviewJournal of the American College of Cardiology2015

Patient selection in heart failure with preserved ejection fraction clinical trials.

Jacob P Kelly, Robert J Mentz, Alexandre Mebazaa, Adriaan A Voors, Javed Butler, Lothar Roessig, Mona Fiuzat, Faiez Zannad, Bertram Pitt, Christopher M O'Connor and 1 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American College of Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03048032 (Diagnostic and Prognostic Value of Cardiac Biomarkers and Echocardiography for Patients Hospitalized Due to Acute Dyspnea), which is not on this map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03048032 completednot on this map

Diagnostic and Prognostic Value of Cardiac Biomarkers and Echocardiography for Patients Hospitalized Due to Acute Dyspnea: Prospective Observational Multicenter Cohort Study

TypeobservationalSponsorVilnius UniversityRan2015 to 2018Enrolled1,566ConditionsAcute Heart FailureArmsBlood sampling, Echocardiography exam
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Confirm Rx insertable cardiac monitor for primary atrial fibrillation detection in high-risk heart failure patients (Confirm-AF trial).Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jacob P KellyDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina. Electronic address: jacob.kelly@dm.duke.edu.
Robert J MentzDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Alexandre MebazaaDepartment of Anesthesia and Critical Care, University Paris Diderot, Sorbonne Paris Cité, Paris, France.
Adriaan A VoorsDepartment of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
Javed ButlerCardiology Division, Stony Brook University, Stony Brook, New York.
Lothar RoessigGlobal Clinical Development, Bayer Pharma AG, Berlin, Germany.
Mona FiuzatDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Faiez ZannadINSERM, Centre d'Investigations Cliniques, Université de Lorraine and CHU de Nancy, Nancy, France.
Bertram PittUniversity of Michigan School of Medicine, Ann Arbor, Michigan.
Christopher M O'ConnorDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Carolyn S P LamDepartment of Cardiology, National Heart Centre Singapore, Singapore.

Funding

MULTIDISCIPLINARY HEART &VASCULAR DISEASEST32HL007101 · NHLBI · DUKE UNIVERSITY · PI FREEDMAN, NEIL J. · 1985 to 2020
$9.8M
NHLBI NIH HHS 5 T32 HL 7101-39NHLBI NIH HHS T32 HL007101
6 · The paper itself

Abstract

Recent clinical trials in patients with heart failure with preserved ejection fraction (HFpEF) have provided important insights into participant selection strategies. Historically, HFpEF trials have included patients with relatively preserved left ventricular ejection fraction ranging from 40% to 55% and a clinical history of heart failure. Contemporary HFpEF trials have also incorporated inclusion criteria such as hospitalization for HFpEF, altered functional capacity, cardiac structural and functional abnormalities, and abnormalities in neurohormonal status (e.g., elevated natriuretic peptide levels). Careful analyses of the effect of these patient selection criteria on outcomes in prior trials provide valuable lessons for future trial design. We review recent and ongoing HFpEF clinical trials from a patient selection perspective and appraise trial patient selection methodologies in relation to outcomes. This review reflects discussions between clinicians, scientists, trialists, regulators, and regulatory representatives at the 10th Global CardioVascular Clinical Trialists Forum in Paris, France, on December 6, 2013.

Indexed as

Patient SelectionStroke VolumeAtrial FibrillationClinical Trials as TopicHeart FailureHemodynamicsHumansNatriuretic PeptidesNatriuretic Peptidesclinical protocolsmethodologynatriuretic peptidespatient selection

Identifiers

PMID25908073
PMCPMC4713836

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.