Evidence map›Paper›PMID 25907910›Full record

ReviewNeurologic clinics2015

Management of unbled brain arteriovenous malformation study.

J P Mohr, Shadi Yaghi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurologic clinics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Grades of brain arteriovenous malformations and risk of hemorrhage and death.Annals of clinical and translational neurology · 2019
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

J P MohrDepartment of Neurology, Doris & Stanley Tananbaum Stroke Center, Neurological Institute, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA. Electronic address: jpm10@columbia.edu.
Shadi YaghiDepartment of Neurology, Doris & Stanley Tananbaum Stroke Center, Neurological Institute, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA.

Funding

A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA)U01NS051483 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOHR, JAY P · 2006 to 2013
$5.5M
New York Stroke Trials Network of Columbia and Cornell (NYCCSTN)U10NS086728 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARSHALL, RANDOLPH S · 2013 to 2017
$2.0M
NINDS NIH HHS U01 NS051483NINDS NIH HHS U10 NS086728
6 · The paper itself

Abstract

In a recent trial limited to arteriovenous malformations discovered not to have bled, medical management was superior to medical management plus intervention. The trial was halted after 226 randomizations and a mean follow-up of 3.3 years owing to a disparity favoring the medical arm. Eligible patients were selected as suitable for lesion eradication. The initial sample size of 800 and follow-up plans for a mean of 7 years were lowered and shortened, respectively, by the outcome data. An application for extended follow-up was given poor priority scores owing to estimations that the disparities in outcomes would not change significantly.

Indexed as

Randomized Controlled Trials as TopicEarly Termination of Clinical TrialsHumansIntracranial Arteriovenous MalformationsArteriovenous malformationInterventional managementMedical managementNonhemorrhagic presentationRandomized clinical trial

Identifiers

PMID25907910
PMCPMC4409652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.