Evidence map›Paper›PMID 25907800›Full record

ArticleNature communications2015

Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.

Zhongbin Deng, Jingyao Mu, Michael Tseng, Binks Wattenberg, Xiaoying Zhuang, Nejat K Egilmez, Qilong Wang, Lifeng Zhang, James Norris, Haixun Guo and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Zhongbin DengJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.
Jingyao MuJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.
Michael TsengDepartment of Anatomical Sciences and Neurobiology, University of Louisville, Kentucky 40202, USA.
Binks Wattenberg1] James Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA [2] The Departments of Medicine, Biochemistry and Molecular Genetics, and Pharmacology and Toxicology, University of Louisville, Kentucky 40202, USA.
Xiaoying ZhuangJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.
Nejat K EgilmezJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.
Qilong WangJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.
Lifeng ZhangJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.
James NorrisDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Haixun GuoJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.
Jun YanJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.ORCID 000000032922422X
Bodduluri HaribabuJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.
Donald MillerJames Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA.
Huang-Ge Zhang1] James Graham Brown Cancer Center, Department of Microbiology &Immunology, University of Louisville, Kentucky 40202, USA [2] Robley Rex VA Medical Center, Louisville, Kentucky 40206, USA.

Funding

Curcumin reverses tumor exosomes-mediated inhibition of myeloid differentiationR01AT004294 · NCCIH · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2007 to 2010
$1.4M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH2TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI GUO, PEIXUAN, ZHANG, HUANG-GE · 2013 to 2014
$867k
Exosomal TRAF2-CSN5 complex mediated inflammation promotes tumor growthI01BX000962 · VA · LOUISVILLE VA MEDICAL MEDICAL CENTER · PI ZHANG, HUANG-GE · 2011 to 2014
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BLRD VA I01 BX000962NCATS NIH HHS UH2 TR000875NCATS NIH HHS UH2TR000875NCCIH NIH HHS R01 AT004294NCCIH NIH HHS R01AT004294
6 · The paper itself

Abstract

Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDENs (intestinal mucosa-derived exosome-like nanoparticles) containing elevated levels of sphingosine-1-phosphate, CCL20 and prostaglandin E2 (PGE2). CCL20 and PGE2 are required for the recruitment and proliferation, respectively, of Th17 cells, and these processes also involve the MyD88-mediated pathway. By influencing the recruitment and proliferation of Th17 cells in the intestine, IDENs promote colon cancer. We demonstrate the biological effect of sphingosine-1-phosphate contained in IDENs on tumour growth in spontaneous and transplanted colon cancer mouse models. These findings provide deeper insights into how host-microbe relationships are mediated by particles secreted from both bacterial and host cells.

Indexed as

AdenocarcinomaAnimalsAzoxymethaneBacteroides fragilisBlotting, WesternCarcinogenesisCarcinogensCell Line, TumorCell ProliferationChemokine CCL20ColitisColonic NeoplasmsDextran SulfateDinoprostoneDisease Models, AnimalEnterobacteriaceaeAzoxymethaneCarcinogensCCL20 protein, mouseChemokine CCL20Dextran SulfateDinoprostoneLysophospholipidsMyd88 protein, mouseMyeloid Differentiation Factor 88Sphingosinesphingosine 1-phosphate

Identifiers

PMID25907800
PMCPMC4410277

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.