Evidence map›Paper›PMID 25907758›Full record

ReviewProteomics. Clinical applications2015

Changing the concepts of immune-mediated glomerular diseases through proteomics.

Dawn J Caster, Liliane Hobeika, Jon B Klein, David W Powell, Kenneth R McLeish

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Proteomics. Clinical applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dawn J CasterDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
Liliane HobeikaDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
Jon B KleinDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
David W PowellDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
Kenneth R McLeishDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
University of Louisville · USLouisville VA Medical Center · US

Funding

Functional Mechanisms of Causal Variants in Systemic Lupus ErythematosusR01AR063124 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2012 to 2016
$2.0M
Discovery & Validation of Biomarkers of Kidney PathologyU01DK096927 · NIDDK · OHIO STATE UNIVERSITY · PI ROVIN, BRAD H · 2013 to 2017
$2.0M
Forecasters of futute and progressive CDK in patients with microvascular glomerulU01DK085673 · NIDDK · OHIO STATE UNIVERSITY · PI KLEIN, JON, ROVIN, BRAD H · 2009 to 2013
$2.0M
Identification of diagnostic markers for lupus nephritisR21AI103980 · NIAID · UNIVERSITY OF LOUISVILLE · PI MCLEISH, KENNETH R, POWELL, DAVID W. · 2013 to 2014
$422k
Mechanism of Neutrophil ActivationI01BX001838 · VA · LOUISVILLE VA MEDICAL MEDICAL CENTER · PI MCLEISH, KENNETH R · 2013 to 2016
–
BLRD VA I01 BX001838NIAID NIH HHS AI-103980NIAID NIH HHS R21 AI103980NIAMS NIH HHS AR-063124NIAMS NIH HHS R01 AR063124NIDDK NIH HHS U01 DK085673NIDDK NIH HHS U01-DK085673NIDDK NIH HHS U01 DK096927NIDDK NIH HHS U01-DK096927NIDDK NIH HHS UM1-DK100865
6 · The paper itself

Abstract

Standard classification of glomerular diseases is based on histopathologic abnormalities. The recent application of proteomic technologies has resulted in paradigm changes in the understanding and classification of idiopathic membranous nephropathy and membranoproliferative glomerulonephritis. Those examples provide evidence that proteomics will lead to advances in understanding of the molecular basis of other glomerular diseases, such as lupus nephritis. Proof of principle experiments show that proteomics can be applied to patient renal biopsy specimens. This viewpoint summarizes the advances in immune-mediated glomerular diseases that have relied on proteomics, and potential future applications are discussed.

Indexed as

AnimalsHumansKidney DiseasesKidney GlomerulusProteomicsAntigen identificationAutoimmunityGlomerulonephritisImmune complex

Identifiers

PMID25907758
PMCPMC4618780
OpenAlexW2056394017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.