Evidence map›Paper›PMID 25907703›Full record

ReviewNature reviews. Rheumatology2015

Kawasaki disease: insights into pathogenesis and approaches to treatment.

Stanford T Shulman, Anne H Rowley

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 6 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 6 syntheses or guidelines pooled it, 214 citations in OpenAlex.

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  20. Impact of breastfeeding andFrontiers in immunology · 2026
    Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Stanford T ShulmanDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, 225 East Chicago Avenue, Box 20, Chicago, IL 60611, USA.
Anne H RowleyDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, 225 East Chicago Avenue, Box 20, Chicago, IL 60611, USA.
Northwestern University · US

Funding

The Pathogenesis of Kawasaki DiseaseR01HL063771 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROWLEY, ANNE H · 2000 to 2011
$3.6M
Deep Sequencing of Kawasaki Disease TissuesR21HL109955 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROWLEY, ANNE H · 2011 to 2012
$437k
The Pathogenesis of Kawasaki DiseaseR56AI106030 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROWLEY, ANNE H · 2014 to 2014
$401k
NHLBI NIH HHS HL109955NHLBI NIH HHS HL63771NIAID NIH HHS AI106030
6 · The paper itself

Abstract

This Review summarizes recent advances in understanding of the pathologic processes and pathophysiologic mechanisms leading to coronary arteritis in Kawasaki disease, and describes current approaches to its treatment. Kawasaki disease is the most common cause of acquired heart disease among children in developed countries, in whom the resulting coronary artery abnormalities can cause myocardial ischaemia, infarction and even death. Epidemiologic data strongly suggest an infectious aetiology, although the causative agent has yet to be identified. Genetic factors also increase susceptibility to Kawasaki disease, as indicated by its strikingly high incidence rate in children of Asian ethnicity and by an increased incidence in first-degree family members. The treatment of Kawasaki disease is based on timely administration of intravenous immunoglobulin and aspirin. However, the management of patients who do not respond to this standard therapy remains challenging; although several options are available, comparative data on which to base treatment decisions are scarce. The added value of adjunctive therapy with corticosteroids in patients at particularly high risk of coronary complications has been demonstrated in Japanese populations, but identification of high-risk patients has proven to be difficult in ethnically diverse populations.

Indexed as

HumansMucocutaneous Lymph Node Syndrome

Identifiers

PMID25907703
OpenAlexW2152966648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.