ArticleEnvironmental science and pollution research international2015
Phototransformation of mefenamic acid induced by nitrite ions in water: mechanism, toxicity, and degradation pathways.
Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Environmentally Safe Photodynamic Control ofMolecules (Basel, Switzerland) · 2022Article
- Electro-transformation of mefenamic acid drug: a case study of kinetics, transformation products, and toxicity.Environmental science and pollution research international · 2019Article
- Aquatic photodegradation of clofibric acid under simulated sunlight irradiation: kinetics and mechanism analysis.RSC advances · 2018Article
- Analysis of the Metabolites of Indole Degraded by an IsolatedBioMed research international · 2017Article
- Photodegradation of gemfibrozil in aqueous solution under UV irradiation: kinetics, mechanism, toxicity, and degradation pathways.Environmental science and pollution research international · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, we evidenced the photo-induced degradation of mefenamic acid, a nonsteroidal anti-inflammatory drug, through the 254-nm light excitation of nitrite. The results demonstrated that the photodegradation of mefenamic acid was enhanced, and the mefenamic acid photodegradation rate significantly increased, from 0.00627 to 0.0350 min(-1) as the nitrite was increased from 0 to 0.5 mmol L(-1). The photodegradation rate increased from 0.0287 to 0.0512 min(-1) as the pH was elevated, from 5.0 to 10.0. The actual second-order rate constant for the reaction of mefenamic acid with ·OH was investigated to 1.079 × 10(10) M(-1) s(-1) according to steady-state ·OH concentration of 3.5 × 10(-14) mmol L(-1) and the contribution to the rate of ·OH of 67.1%. The photoproducts were identified using HPLC/MS/MS, and possible nitrite-induced photodegradation pathways were proposed by hydroxylation, dehydrogenation, hydration, nitrosylation, and ketonized reactions. The toxicity of the phototransformation products was evaluated using the Microtox test, which revealed that the photoproducts were more toxic than mefenamic acid for the generation of nitrosation aromatic compounds.
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