Evidence map›Paper›PMID 25907521›Full record

ArticleAJNR. American journal of neuroradiology2015

Statin therapy does not affect the radiographic and clinical profile of patients with TIA and minor stroke.

N Asdaghi, J I Coulter, J Modi, M C Camden, A Qazi, M Goyal, T Rundek, S B Coutts

Open access · hybridAbstract readClinical StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

N AsdaghiFrom the Departments of Clinical Neurosciences (N.A., J.I.C., M.C.C., A.Q., M.G., S.B.C.) Division of Cerebrovascular Disease (N.A., T.R.), Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida. nasdaghi@med.miami.edu.
J I CoulterFrom the Departments of Clinical Neurosciences (N.A., J.I.C., M.C.C., A.Q., M.G., S.B.C.).
J ModiRadiology (J.M., M.G., S.B.C.).
M C CamdenFrom the Departments of Clinical Neurosciences (N.A., J.I.C., M.C.C., A.Q., M.G., S.B.C.).
A QaziFrom the Departments of Clinical Neurosciences (N.A., J.I.C., M.C.C., A.Q., M.G., S.B.C.).
M GoyalFrom the Departments of Clinical Neurosciences (N.A., J.I.C., M.C.C., A.Q., M.G., S.B.C.) Radiology (J.M., M.G., S.B.C.).
T RundekDivision of Cerebrovascular Disease (N.A., T.R.), Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida.
S B CouttsFrom the Departments of Clinical Neurosciences (N.A., J.I.C., M.C.C., A.Q., M.G., S.B.C.) Radiology (J.M., M.G., S.B.C.) Hotchkiss Brain Institute (S.B.C.), University of Calgary, Calgary, Alberta, Canada.
University of Calgary · CA

Funding

Genetics Determinants of Extreme Phenotypes of Subclinical AtherosclerosisK24NS062737 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA · 2009 to 2013
$975k
Canadian Institutes of Health Research MOP-89937NINDS NIH HHS K24 NS 062737NINDS NIH HHS K24 NS062737
6 · The paper itself

Abstract

background and purposeAcute statin therapy improves neurologic outcome and diminishes infarct growth in animal models of stroke. Clinical studies suggest that premorbid and early statin use is associated with improved outcome after major stroke. We studied the association between statin therapy and radiographic and clinical outcomes in patients with high-risk TIA and minor stroke. MATERIALS AND

methodsPatients with high-risk TIA and minor stroke (NIHSS ≤3) were prospectively enrolled within 24 hours of symptom onset. Patients were followed clinically for 3 months, and a subset had a repeat MR imaging at 90 days.

resultsOf 418 patients, 23% were prescribed statins before their stroke. Statins were continued in 20% and initiated in 42%. Patients on prior statin therapy were older and more hypertensive, treated with aspirin, and more likely to have symptomatic carotid disease compared with those not on statin. Adjusting for these differences, prior statin treatment was not associated with DWI positivity (adjusted OR = 1.3; 95% CI, 0.77-2.1; P = .32) or smaller median baseline infarct volume, 1.1 mL (interquartile range = 4) versus 1 mL (interquartile range = 2.5; P = .56). Early or continued treatment with statins did not improve the risk of clinical deterioration (adjusted OR = 0.66; 95% CI, 0.27-1.6; P = .35) or poor functional outcome at 3 months (adjusted OR = 0.66; 95% CI, 0.35-1.24; P = .19).

conclusionsPrestroke or early-stroke statin therapy was not associated with a reduction in the number of DWI lesions, infarct volume, or improved clinical or functional outcome at 3 months. The effect of acute statin treatment in patients with ischemic stroke/TIA remains unclear and needs further investigation.

Indexed as

Diffusion Magnetic Resonance ImagingEarly Medical InterventionTomography, X-Ray ComputedAgedAged, 80 and overDisease ProgressionFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIschemic Attack, TransientMaleMiddle AgedNeurologic ExaminationRecurrenceStrokeTreatment OutcomeHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID25907521
PMCPMC8013021
OpenAlexW2103565597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.