Evidence map›Paper›PMID 25907126›Full record

Observational studyJournal of the American Heart Association2015

Years of able life in older persons--the role of cardiovascular imaging and biomarkers: the Cardiovascular Health Study.

Laith I Alshawabkeh, Laura M Yee, Julius M Gardin, John S Gottdiener, Michelle C Odden, Traci M Bartz, Alice M Arnold, Kenneth J Mukamal, Robert B Wallace

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Recovery From Mobility Limitation in Middle-Aged African Americans: The Jackson Heart Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Laith I AlshawabkehDivision of Cardiovascular Medicine, University of Iowa, Iowa City, IA (L.I.A.) Carver College of Medicine and the College of Public Health, University of Iowa, Iowa City, IA (L.I.A., R.B.W.).
Laura M YeeDepartment of Biostatistics, University of Washington, Seattle, WA (L.M.Y., T.M.B., A.M.A.).
Julius M GardinDepartment of Medicine, Hackensack University Medical Center, Hackensack, NJ (J.M.G.).
John S GottdienerDivision of Cardiovascular Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD (J.S.G.).
Michelle C OddenSchool of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR (M.C.O.).
Traci M BartzDepartment of Biostatistics, University of Washington, Seattle, WA (L.M.Y., T.M.B., A.M.A.).
Alice M ArnoldDepartment of Biostatistics, University of Washington, Seattle, WA (L.M.Y., T.M.B., A.M.A.).
Kenneth J MukamalDivisions of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (K.J.M.).
Robert B WallaceDepartment of Internal Medicine, University of Iowa, Iowa City, IA (R.B.W.) Carver College of Medicine and the College of Public Health, University of Iowa, Iowa City, IA (L.I.A., R.B.W.).
University of Washington · USUniversity of Iowa · USHackensack University Medical Center · USHarvard University · USOregon State University · USUniversity of Maryland, Baltimore · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Role of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9M
Modeling Optimal Strategies to Prevent Cardiovascular Events in Older AdultsK01AG039387 · NIA · OREGON STATE UNIVERSITY · PI ODDEN, MICHELLE CHRISTINA · 2012 to 2016
$688k
CHS-Transition PhaseN01HC55222 · NHLBI · PI , · 2007 to 2007
$575k
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R56AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2010 to 2010
$300k
CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84N01HC085082 · HC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KULLER, LEWIS H · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085081 · HC · JOHNS HOPKINS UNIVERSITY · PI FRIED, LINDA P · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · HC · UNIVERSITY OF WASHINGTON · 1988 to 2005
–
NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL080295NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC55222NHLBI NIH HHS R01 HL080295NHLBI NIH HHS U01 HL080295NIA NIH HHS AG023629NIA NIH HHS K01 AG039387NIA NIH HHS R01 AG023629NIA NIH HHS R56 AG023629NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

backgroundAs the U.S. population grows older, there is greater need to examine physical independence. Previous studies have assessed risk factors in relation to either disability or mortality, but an outcome that combines both is still needed. METHODS AND

resultsThe Cardiovascular Health Study is a population-based, prospective study where participants underwent baseline echocardiogram, measurement of carotid intima-media thickness (IMT), and various biomarkers, then followed for up to 18 years. Years of able life (YAL) constituted the number of years the participant was able to perform all activities of daily living. Linear regression was used to model the relationship between selected measures and outcomes, adjusted for confounding variables. Among 4902 participants, mean age was 72.6 ± 5.4 years, median YAL for males was 8.8 (interquartile range [IQR], 4.3 to 13.8) and 10.3 (IQR, 5.8 to 15.8) for females. Reductions in YAL in the fully adjusted model for females and males, respectively, were: -1.34 (95% confidence interval [CI], -2.18, -0.49) and -1.41 (95% CI, -2.03, -0.8) for abnormal left ventricular (LV) ejection fraction, -0.5 (95% CI, -0.78, -0.22) and -0.62 (95% CI, -0.87, -0.36) per SD increase in LV mass, -0.5 (95% CI, -0.7, -0.29) and -0.79 (95% CI, -0.99, -0.58) for IMT, -0.5 (95% CI, -0.64, -0.37) and -0.79 (95% CI, -0.94, -0.65) for N-terminal pro-brain natriuretic peptide, -1.08 (95% CI, -1.34, -0.83) and -0.73 (95% CI, -0.97, -0.5) for high-sensitivity troponin-T, and -0.26 (95% CI, -0.42, -0.09) and -0.23 (95% CI, -0.41, -0.05) for procollagen-III N-terminal propeptide. Most tested variables remained significant even after adjusting for incident cardiovascular (CV) disease.

conclusionsIn this population-based cohort, variables obtained by CV imaging and biomarkers of inflammation, coagulation, atherosclerosis, myocardial injury and stress, and cardiac collagen turnover were associated with YAL, an important outcome that integrates physical ability and longevity in older persons.

Indexed as

EchocardiographyActivities of Daily LivingAgedBiomarkersCardiovascular DiseasesCarotid Intima-Media ThicknessFemaleHumansIndependent LivingMaleNatriuretic Peptide, BrainPeptide FragmentsProcollagenProspective StudiesStroke VolumeTroponin IBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Procollagenprocollagen Type III-N-terminal peptideTroponin Iactivities of daily livingagingbiomarkersimaging

Identifiers

PMID25907126
PMCPMC4579951
OpenAlexW2109201588

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.