ArticleReproductive biology and endocrinology : RB&E2015
Prospectively assessing risk for premature ovarian senescence in young females: a new paradigm.
Article in Reproductive biology and endocrinology : RB&E, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Spontaneous Premature Ovarian Insufficiency: Methods Under Research for Infertility Treatment.Journal of clinical medicine · 2026Review
- Association of Deficiency in Vitamin D, Vitamin E, and Selenium Levels With Premature Ovarian Insufficiency: A Systematic Review.Health science reports · 2025Review
- Article
- Transcriptomic profile of premature ovarian insufficiency with RNA-sequencing.Frontiers in cell and developmental biology · 2024Article
- Facilitation of Ovarian Response by Mechanical Force-Latest Insight on Fertility Improvement in Women with Poor Ovarian Response or Primary Ovarian Insufficiency.International journal of molecular sciences · 2023Review
- Machine Learning-Based Approach Highlights the Use of a Genomic Variant Profile for Precision Medicine in Ovarian Failure.Journal of personalized medicine · 2021Article
- Review
- An adolescent girl with premature ovarian failure, Graves' disease, and chronic urticaria: a case report.Journal of medical case reports · 2020Article
- Premature ovarian insufficiency (POI) and autoimmunity-an update appraisal.Journal of assisted reproduction and genetics · 2019Review
- Autoimmune premature ovarian failure.Przeglad menopauzalny = Menopause review · 2016Review
- Length of FMR1 repeat alleles within the normal range does not substantially affect the risk of early menopause.Human reproduction (Oxford, England) · 2016Article
- Correlation of normal-range FMR1 repeat length or genotypes and reproductive parameters.Journal of assisted reproduction and genetics · 2016Article
- Is FMR1 CGG repeat length a predictor of in vitro fertilization stimulation response or outcome?Fertility and sterility · 2016Article
- Article
- Occult Form of Premature Ovarian Insufficiency in Women with Infertility and Oligomenorrhea as Assessed by Poor Ovarian Response Criteria.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
backgroundApproximately 10% of women suffer from premature ovarian senescence (POS), ca. 9% as occult primary ovarian insufficiency (OPOI, also called premature ovarian aging, POA) and ca. 1% as primary ovarian insufficiency (POI, also called premature ovarian failure, POF). In a large majority of cases POS is currently only diagnosed at advanced clinical stages when women present with clinical infertility.
methodsWe here, based on published evidence, suggest a new diagnostic paradigm, which is based on identifying young women at increased risk for POS at much earlier stages.
resultsRisk factors for POS are known from the literature, and can be used to identify a sub-group of young women at increased risk, who then are followed sequentially with serial assessments of functional ovarian reserve (FOR) until a diagnosis of POS is either reached or refuted. At approximately 25% prevalence in general U.S. populations (and somewhat different prevalence rates in more homogenous Asian and African populations), so-called low (CGGn<26) mutations of the fragile X mental retardation 1 (FMR1) gene, likely, represents the most common known risk factor, including history-based risk factors from medical, genetic and family histories.
conclusionsWomen so affirmatively diagnosed with POS at relative young ages, then have the opportunity to reconsider their reproductive planning and/or choose fertility preservation via oocyte or ovarian tissue cryopreservation at ages when such procedures are clinically much more effective and, therefore, also more cost-effective. Appropriate validation studies will have to precede widespread utilization of this paradigm.
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