ArticleInternational journal of epidemiology2015
Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour.
Article in International journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity.EBioMedicine · 2017Trial
- The emergence of developmental behavioral epigenomics.Epigenomics · 2022Article
- Maternal immune activation and neuroinflammation in human neurodevelopmental disorders.Nature reviews. Neurology · 2021Review
- Genetic and epigenetic factors and early life inflammation as predictors of neurodevelopmental outcomes.Seminars in fetal & neonatal medicine · 2020Review
- Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross-sectional study.Brain and behavior · 2020Article
- Vegetarian Diet during Pregnancy Is Not Associated with Poorer Cognitive Performance in Children at Age 6-7 Years.Nutrients · 2019Observational
- Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood.International journal of obesity (2005) · 2019Article
- Gene expression in cord blood links genetic risk for neurodevelopmental disorders with maternal psychological distress and adverse childhood outcomes.Brain, behavior, and immunity · 2018Article
- In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators.Environmental research · 2018Article
- Arachidonic acid and DHA status in pregnant women is not associated with cognitive performance of their children at 4 or 6-7 years.The British journal of nutrition · 2018Article
- Preconception Maternal Iodine Status Is Positively Associated with IQ but Not with Measures of Executive Function in Childhood.The Journal of nutrition · 2018Article
- Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life.PloS one · 2018Article
- DNA methylation signatures of educational attainment.NPJ science of learning · 2018Article
- Epigenome-wide analysis in newborn blood spots from monozygotic twins discordant for cerebral palsy reveals consistent regional differences in DNA methylation.Clinical epigenetics · 2018Article
- Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children's health in India and Sub-Saharan Africa.BMC nutrition · 2017Article
- Review
- How to make DNA methylome wide association studies more powerful.Epigenomics · 2016Review
- From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive.International journal of epidemiology · 2015Article
- miR-381 Regulates Neural Stem Cell Proliferation and Differentiation via Regulating Hes1 Expression.PloS one · 2015Article
- Placental 5-methylcytosine and 5-hydroxymethylcytosine patterns associate with size at birth.Epigenetics · 2015Article
Corrections and comments
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Authors and funding
24 authors at 10 institutions in 4 countries.
Funding
Abstract
backgroundEarly life environments induce long-term changes in neurocognitive development and behaviour. In animal models, early environmental cues affect neuropsychological phenotypes via epigenetic processes but, as yet, there is little direct evidence for such mechanisms in humans.
methodWe examined the relation between DNA methylation at birth and child neuropsychological outcomes in two culturally diverse populations using a genome-wide methylation analysis and validation by pyrosequencing.
resultsWithin the UK Southampton Women's Survey (SWS) we first identified 41 differentially methylated regions of interest (DMROI) at birth associated with child's full-scale IQ at age 4 years. Associations between HES1 DMROI methylation and later cognitive function were confirmed by pyrosequencing in 175 SWS children. Consistent with these findings, higher HES1 methylation was associated with higher executive memory function in a second independent group of 200 SWS 7-year-olds. Finally, we examined a pathway for this relationship within a Singaporean cohort (n = 108). Here, HES1 DMROI methylation predicted differences in early infant behaviour, known to be associated with academic success. In vitro, methylation of HES1 inhibited ETS transcription factor binding, suggesting a functional role of this site.
conclusionsThus, our findings suggest that perinatal epigenetic processes mark later neurocognitive function and behaviour, providing support for a role of epigenetic processes in mediating the long-term consequences of early life environment on cognitive development.
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