ArticleThe New phytologist2015
Spatiotemporal modelling of hormonal crosstalk explains the level and patterning of hormones and gene expression in Arabidopsis thaliana wild-type and mutant roots.
Article in The New phytologist, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- POLARIS is a copper-binding peptide that interacts with ETR1 to negatively regulate ethylene signaling in Arabidopsis.Plant communications · 2025Article
- From Hormones to Harvests: A Pathway to Strengthening Plant Resilience for Achieving Sustainable Development Goals.Plants (Basel, Switzerland) · 2025Review
- Computational modeling of plant root development: the art and the science.The New phytologist · 2025Review
- MDF Regulates a Network of Auxin-Dependent and Auxin-Independent Pathways of Adventitious Root Regeneration inPlant direct · 2025Article
- Modeling Arabidopsis root growth and development.Plant physiology · 2025Review
- The Constrained Disorder Principle Overcomes the Challenges of Methods for Assessing Uncertainty in Biological Systems.Journal of personalized medicine · 2024Review
- A predictive model for ethylene-mediated auxin and cytokinin patterning in the Arabidopsis root.Plant communications · 2024Article
- ZmPILS6 is an auxin efflux carrier required for maize root morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- From the archives: A rice grain size regulatory module, GWAS of primary plant metabolism, and promoter trapping of polarity markers.The Plant cell · 2022Article
- Systems approaches reveal that ABCB and PIN proteins mediate co-dependent auxin efflux.The Plant cell · 2022Article
- Modeling Auxin Signaling in Roots: Auxin Computations.Cold Spring Harbor perspectives in biology · 2022Review
- Root growth responses to mechanical impedance are regulated by a network of ROS, ethylene and auxin signalling in Arabidopsis.The New phytologist · 2021Article
- Bootstrapping and Pinning down the Root Meristem; the Auxin-PLT-ARR Network Unites Robustness and Sensitivity in Meristem Growth Control.International journal of molecular sciences · 2021Article
- Cytokinin-Controlled Gradient Distribution of Auxin inInternational journal of molecular sciences · 2021Review
- Gibberellin signaling mediates lateral root inhibition in response to K+-deprivation.Plant physiology · 2021Article
- Differential Subcellular Distribution of Cytokinins: How Does Membrane Transport Fit into the Big Picture?International journal of molecular sciences · 2021Review
- All Roads Lead to Auxin: Post-translational Regulation of Auxin Transport by Multiple Hormonal Pathways.Plant communications · 2020Review
- Auxin fluxes through plasmodesmata modify root-tip auxin distribution.Development (Cambridge, England) · 2020Article
- How grass keeps growing: an integrated analysis of hormonal crosstalk in the maize leaf growth zone.The New phytologist · 2020Article
- Salicylic Acid Affects Root Meristem Patterning via Auxin Distribution in a Concentration-Dependent Manner.Plant physiology · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Patterning in Arabidopsis root development is coordinated via a localized auxin concentration maximum in the root tip, requiring the regulated expression of specific genes. However, little is known about how hormone and gene expression patterning is generated. Using a variety of experimental data, we develop a spatiotemporal hormonal crosstalk model that describes the integrated action of auxin, ethylene and cytokinin signalling, the POLARIS protein, and the functions of PIN and AUX1 auxin transporters. We also conduct novel experiments to confirm our modelling predictions. The model reproduces auxin patterning and trends in wild-type and mutants; reveals that coordinated PIN and AUX1 activities are required to generate correct auxin patterning; correctly predicts shoot to root auxin flux, auxin patterning in the aux1 mutant, the amounts of cytokinin, ethylene and PIN protein, and PIN protein patterning in wild-type and mutant roots. Modelling analysis further reveals how PIN protein patterning is related to the POLARIS protein through ethylene signalling. Modelling prediction of the patterning of POLARIS expression is confirmed experimentally. Our combined modelling and experimental analysis reveals that a hormonal crosstalk network regulates the emergence of patterns and levels of hormones and gene expression in wild-type and mutants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.