ArticlePancreas2015
In vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa.
Article in Pancreas, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Trial
- Hybrid Raman and Partial Wave Spectroscopy Microscope for the Characterization of Molecular and Structural Alterations in Tissue.Journal of biophotonics · 2024Article
- Fully automated fiber-based optical spectroscopy system for use in a clinical setting.Journal of biomedical optics · 2018Article
- Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.Nature reviews. Gastroenterology & hepatology · 2017Review
- Microscope objective based 4Biomedical optics express · 2017Article
- Current Status and Future Directions for Screening Patients at High Risk for Pancreatic Cancer.Gastroenterology & hepatology · 2017Article
- Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy.Nature biomedical engineering · 2017Article
- Using electron microscopy to calculate optical properties of biological samples.Biomedical optics express · 2016Article
- Fractal Characterization of Chromatin Decompaction in Live Cells.Biophysical journal · 2015Article
- Subdiffusion reflectance spectroscopy to measure tissue ultrastructure and microvasculature: model and inverse algorithm.Journal of biomedical optics · 2015Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo reduce pancreatic cancer mortality, a paradigm shift in cancer screening is needed. Our group pioneered the use of low-coherence enhanced backscattering (LEBS) spectroscopy to predict the presence of pancreatic cancer by interrogating the duodenal mucosa. A previous ex vivo study (n = 203) demonstrated excellent diagnostic potential: sensitivity, 95%; specificity, 71%; and accuracy, 85%. The objective of the current case-control study was to evaluate this approach in vivo.
methodsWe developed a novel endoscope-compatible fiber-optic probe to measure LEBS in the periampullary duodenum of 41 patients undergoing upper endoscopy. This approach enables minimally invasive detection of the ultrastructural consequences of pancreatic field carcinogenesis.
resultsThe LEBS parameters and optical properties were significantly altered in patients harboring adenocarcinomas (including early-stage) throughout the pancreas relative to healthy controls. Test performance characteristics were excellent with sensitivity = 78%, specificity = 85%, and accuracy = 81%. Moreover, the LEBS prediction rule was not confounded by patients' demographics.
conclusionWe demonstrate the feasibility of in vivo measurement of histologically normal duodenal mucosa to predict the presence of adenocarcinoma throughout the pancreas. This represents the next step in establishing duodenal LEBS analysis as a prescreening technique that identifies clinically asymptomatic patients who are at elevated risk of PC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.