ArticlePLoS genetics2015
Cross-population joint analysis of eQTLs: fine mapping and functional annotation.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- Article
- A functional ancestry-linked regulatory haplotype influences CYP2D6 expression.The pharmacogenomics journal · 2026Article
- Deep-learning prediction of gene expression from personal genomes.Genome biology · 2026Article
- Towards improved fine-mapping of candidate causal variants.Nature reviews. Genetics · 2025Review
- Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.Nature genetics · 2025Article
- Exploring the Interplay between the Hologenome and Complex Traits in Bovine and Porcine Animals Using Genome-Wide Association Analysis.International journal of molecular sciences · 2024Article
- Genotype × environment interactions in gene regulation and complex traits.Nature genetics · 2024Review
- Improved multi-ancestry fine-mapping identifiesmedRxiv : the preprint server for health sciences · 2024Article
- Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.Nature genetics · 2024Article
- Characterization of caffeine response regulatory variants in vascular endothelial cells.eLife · 2024Article
- Conditional transcriptome-wide association study for fine-mapping candidate causal genes.Nature genetics · 2024Article
- Regulatory features aid interpretation of 3'UTR variants.American journal of human genetics · 2024Article
- Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture.Nature genetics · 2023Article
- Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs.Nature communications · 2023Article
- Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease.Nature communications · 2023Article
- Article
- Article
- Network regression analysis for binary and ordinal categorical phenotypes in transcriptome-wide association studies.Genetics · 2022Article
- Network regression analysis in transcriptome-wide association studies.BMC genomics · 2022Article
- Fine-mapping from summary data with the "Sum of Single Effects" model.PLoS genetics · 2022Article
10 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
Mapping expression quantitative trait loci (eQTLs) has been shown as a powerful tool to uncover the genetic underpinnings of many complex traits at molecular level. In this paper, we present an integrative analysis approach that leverages eQTL data collected from multiple population groups. In particular, our approach effectively identifies multiple independent cis-eQTL signals that are consistent across populations, accounting for population heterogeneity in allele frequencies and linkage disequilibrium patterns. Furthermore, by integrating genomic annotations, our analysis framework enables high-resolution functional analysis of eQTLs. We applied our statistical approach to analyze the GEUVADIS data consisting of samples from five population groups. From this analysis, we concluded that i) jointly analysis across population groups greatly improves the power of eQTL discovery and the resolution of fine mapping of causal eQTL ii) many genes harbor multiple independent eQTLs in their cis regions iii) genetic variants that disrupt transcription factor binding are significantly enriched in eQTLs (p-value = 4.93 × 10(-22)).
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