Evidence map›Paper›PMID 25906246›Full record

ReviewLab on a chip2015

Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices.

David J Guckenberger, Theodorus E de Groot, Alwin M D Wan, David J Beebe, Edmond W K Young

Abstract readReview
In one paragraph

Review in Lab on a chip, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed.

  1. Article
  2. Exploiting Device Deformability for Fluid and Particle Manipulation.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Augmented 3D Printing for Multiscale Microphysiological Systems.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Advances in Microengineered Platforms for Skin Research.JID innovations : skin science from molecules to population health · 2025
    Review
  17. Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  18. Review
  19. Article
  20. Microbial community interactions on a chip.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David J GuckenbergerDepartment of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI, USA.
Theodorus E de Groot
Alwin M D Wan
David J Beebe
Edmond W K Young

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
Enabling NF-kB Signal Transduction Studies in Primary Multiple Myeloma CellsR01CA155192 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BEEBE, DAVID J, MIYAMOTO, SHIGEKI · 2012 to 2016
$1.4M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA155192NHGRI NIH HHS 5T32HG002760NHGRI NIH HHS T32 HG002760
6 · The paper itself

Abstract

This tutorial review offers protocols, tips, insight, and considerations for practitioners interested in using micromilling to create microfluidic devices. The objective is to provide a potential user with information to guide them on whether micromilling would fill a specific need within their overall fabrication strategy. Comparisons are made between micromilling and other common fabrication methods for plastics in terms of technical capabilities and cost. The main discussion focuses on "how-to" aspects of micromilling, to enable a user to select proper equipment and tools, and obtain usable microfluidic parts with minimal start-up time and effort. The supplementary information provides more extensive discussion on CNC mill setup, alignment, and programming. We aim to reach an audience with minimal prior experience in milling, but with strong interests in fabrication of microfluidic devices.

Indexed as

PlasticsEquipment DesignMicrofluidic Analytical TechniquesMicrotechnologyPlastics

Identifiers

PMID25906246
PMCPMC4439323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.