Evidence map›Paper›PMID 25906089›Full record

ReviewAmerican journal of respiratory and critical care medicine2015

Diffuse Cystic Lung Disease. Part I.

Nishant Gupta, Robert Vassallo, Kathryn A Wikenheiser-Brokamp, Francis X McCormack

Open access · greenAbstract readReview
In one paragraph

Review in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 226 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Translational lung cancer research · 2026
    Article
  4. Article
  5. Article
  6. Isolated Pulmonary Light Chain Deposition Disease.European journal of case reports in internal medicine · 2026
    Article
  7. Article
  8. Article
  9. Review of research on pulmonary cysts in sjögren's syndrome.Journal of cardiothoracic surgery · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Rare interstitial lung diseases: a narrative review.Journal of thoracic disease · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Bevacizumab-induced pulmonary cystic disease.Respirology case reports · 2024
    Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Nishant Gupta1 Division of Pulmonary, Critical Care, and Sleep Medicine and.
Robert Vassallo3 Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota; and.
Kathryn A Wikenheiser-Brokamp4 Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio.
Francis X McCormack1 Division of Pulmonary, Critical Care, and Sleep Medicine and.
Veterans Health Administration · USCincinnati Children's Hospital Medical Center · USMayo Clinic · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
NCATS NIH HHS UL1 TR001425
6 · The paper itself

Abstract

The diffuse cystic lung diseases (DCLDs) are a group of pathophysiologically heterogenous processes that are characterized by the presence of multiple spherical or irregularly shaped, thin-walled, air-filled spaces within the pulmonary parenchyma. Although the mechanisms of cyst formation remain incompletely defined for all DCLDs, in most cases lung remodeling associated with inflammatory or infiltrative processes results in displacement, destruction, or replacement of alveolar septa, distal airways, and small vessels within the secondary lobules of the lung. The DCLDs can be broadly classified according to underlying etiology as those caused by low-grade or high-grade metastasizing neoplasms, polyclonal or monoclonal lymphoproliferative disorders, infections, interstitial lung diseases, smoking, and congenital or developmental defects. In the first of a two-part series, we present an overview of the cystic lung diseases caused by neoplasms, infections, smoking-related diseases, and interstitial lung diseases, with a focus on lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis.

Indexed as

Histiocytosis, Langerhans-CellHumansInfectionsLungLung DiseasesLung Diseases, InterstitialLymphangioleiomyomatosisNeoplasmsSmokinghigh-resolution computed tomographylung cystslymphangioleiomyomatosispulmonary Langerhans cell histiocytosistuberous sclerosis

Identifiers

PMID25906089
PMCPMC5442966
OpenAlexW2159234564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.