Evidence map›Paper›PMID 25905980›Full record

ArticleTransplantation2015

Race, Relationship and Renal Diagnoses After Living Kidney Donation.

Krista L Lentine, Mark A Schnitzler, Amit X Garg, Huiling Xiao, David Axelrod, Janet E Tuttle-Newhall, Daniel C Brennan, Dorry L Segev

Open access · greenAbstract readComparative Study
In one paragraph

Article in Transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Examining post-donation outcomes in Hispanic/Latinx living kidney donors in the United States: A systematic review.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Pooled it
  3. Guideline
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Eliminating Race From eGFR Calculations: Impact on Living Donor Programs.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Apolipoprotein L1: role in the evaluation of kidney transplant donors.Current opinion in nephrology and hypertension · 2020
    Article
  16. Article
  17. The changing landscape of live kidney donation in the United States from 2005 to 2017.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Krista L Lentine1 Center for Outcomes Research, Saint Louis University School of Medicine, St. Louis, MO. 2 Division of Abdominal Transplantation, Department of Surgery, Saint Louis University School of Medicine, St. Louis, MO. 3 Division of Nephrology, Western University, London, ON, Canada. 4 Division of Abdominal Transplantation, Department of Surgery, Dartmouth Hitchcock Medical Center, Hanover, NH. 5 Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO. 6 Division of Abdominal Transplantation, Department of Surgery, Johns Hopkins University, Baltimore, MD.
Mark A Schnitzler
Amit X Garg
Huiling Xiao
David Axelrod
Janet E Tuttle-Newhall
Daniel C Brennan
Dorry L Segev
Dartmouth–Hitchcock Medical Center · USJohns Hopkins University · USSaint Louis University · USSalus (United States) · USWashington University in St. Louis · USWestern University · CA

Funding

Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
NIDDK NIH HHS K24 DK101828NIDDK NIH HHS K24-DK101828NIDDK NIH HHS R01 DK096008NIDDK NIH HHS R01-DK096008
6 · The paper itself

Abstract

backgroundIn response to recent studies, a better understanding of the risks of renal complications among African American and biologically related living kidney donors is needed.

methodsWe examined a database linking U.S. registry identifiers for living kidney donors (1987-2007) to billing claims from a private health insurer (2000-2007 claims) to identify renal condition diagnoses categorized by International Classification of Diseases 9th Revision coding. Cox regression with left and right censoring was used to estimate cumulative incidence of diagnoses after donation and associations (adjusted hazards ratios, aHR) with donor traits.

resultsAmong 4650 living donors, 13.1% were African American and 76.3% were white; 76.1% were first-degree relatives of their recipient. By 7 years post-donation, after adjustment for age and sex, greater proportions of African American compared with white donors had renal condition diagnoses: chronic kidney disease (12.6% vs 5.6%; aHR, 2.32; 95% confidence interval [95% CI], 1.48-3.62), proteinuria (5.7% vs 2.6%; aHR, 2.27; 95% CI, 1.32-3.89), nephrotic syndrome (1.3% vs 0.1%; aHR, 15.7; 95% CI, 2.97-83.0), and any renal condition (14.9% vs 9.0%; aHR, 1.72; 95% CI, 1.23-2.41). Although first-degree biological relationship to the recipient was not associated with renal risk, associations of African American race persisted for these conditions and included unspecified renal failure and reported disorders of kidney dysfunction after adjustment for biological donor-recipient relationship.

conclusionsAfrican Americans more commonly develop renal conditions after living kidney donation, independent of donor-recipient relationship. Continued research is needed to improve risk stratification for renal outcomes among African American living donors.

Indexed as

Black or African AmericanFamilyLiving DonorsWhite PeopleAdultFemaleHumansKidney TransplantationMaleMiddle AgedNephrectomyNephrotic SyndromeProportional Hazards ModelsProteinuriaRegistriesRenal Insufficiency, Chronic

Identifiers

PMID25905980
PMCPMC4663050
OpenAlexW2095516059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.