ArticlePloS one2015
Comprehensive Metabolomic, Lipidomic and Microscopic Profiling of Yarrowia lipolytica during Lipid Accumulation Identifies Targets for Increased Lipogenesis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Multi-Omics Analysis Reveals 1-Propanol-Induced Pentadecanoic Acid Biosynthesis inBiomolecules · 2025Article
- Review
- Nile red-based lipid fluorometry protocol and its use for statistical optimization of lipids in oleaginous yeasts.Applied microbiology and biotechnology · 2023Article
- Lipid Readjustment inBiomolecules · 2022Article
- Review
- Combined Metabolome and Lipidome Analyses for In-Depth Characterization of Lipid Accumulation in the DHA ProducingMetabolites · 2021Article
- Current Pretreatment/Cell Disruption and Extraction Methods Used to Improve Intracellular Lipid Recovery from Oleaginous Yeasts.Microorganisms · 2021Review
- Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world.Metabolomics : Official journal of the Metabolomic Society · 2020Review
- Analysis ofFrontiers in cellular and infection microbiology · 2020Article
- In silico identification of metabolic engineering strategies for improved lipid production inBiotechnology for biofuels · 2019Article
- Engineering Yarrowia lipolytica for Use in Biotechnological Applications: A Review of Major Achievements and Recent Innovations.Molecular biotechnology · 2018Review
- An Overview of Current Pretreatment Methods Used to Improve Lipid Extraction from Oleaginous Micro-Organisms.Molecules (Basel, Switzerland) · 2018Review
- The MPLEx Protocol for Multi-omic Analyses of Soil Samples.Journal of visualized experiments : JoVE · 2018Article
- Oleaginicity of the yeast strainBiotechnology for biofuels · 2018Article
- Ameliorating the Metabolic Burden of the Co-expression of Secreted Fungal Cellulases in a High Lipid-AccumulatingFrontiers in microbiology · 2018Article
- Article
- A molecular genetic toolbox forBiotechnology for biofuels · 2017Article
- Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals.Frontiers in microbiology · 2017Review
- Multi-omics analysis reveals regulators of the response to nitrogen limitation in Yarrowia lipolytica.BMC genomics · 2016Article
- Sequence Assembly of Yarrowia lipolytica Strain W29/CLIB89 Shows Transposable Element Diversity.PloS one · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yarrowia lipolytica is an oleaginous ascomycete yeast that accumulates large amounts of lipids and has potential as a biofuel producing organism. Despite a growing scientific literature focused on lipid production by Y. lipolytica, there remain significant knowledge gaps regarding the key biological processes involved. We applied a combination of metabolomic and lipidomic profiling approaches as well as microscopic techniques to identify and characterize the key pathways involved in de novo lipid accumulation from glucose in batch cultured, wild-type Y. lipolytica. We found that lipids accumulated rapidly and peaked at 48 hours during the five day experiment, concurrent with a shift in amino acid metabolism. We also report that exhaustion of extracellular sugars coincided with thickening of the cell wall, suggesting that genes involved in cell wall biogenesis may be a useful target for improving the efficiency of lipid producing yeast strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.