SynthesisScientific reports2015
Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis.
Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Vitamin D and Bladder Cancer Risk: An Umbrella Review and Second Order Meta-Analysis.Cancer medicine · 2026Pooled it
- Pooled it
- Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Association between Dietary Vitamin E Intake and Esophageal Cancer Risk: An Updated Meta-Analysis.Nutrients · 2018Pooled it
- Effects of Vitamin and Antioxidant Supplements in Prevention of Bladder Cancer: a Meta-Analysis of Randomized Controlled Trials.Journal of Korean medical science · 2017Pooled it
- Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses.European journal of epidemiology · 2016Pooled it
- Intersection of Precision Nutrition and Bladder Cancer: A Narrative State-of-the-Art Review of Potential Applications and Challenges.Journal of clinical medicine · 2026Review
- Supplementary selenium and vitamin E in non-muscle-invasive bladder cancer.Nature reviews. Urology · 2024Article
- Exploring micronutrients and microbiome synergy: pioneering new paths in cancer therapy.Frontiers in immunology · 2024Review
- Relationship between Bladder Cancer, Nutritional Supply, and Treatment Strategies: A Comprehensive Review.Nutrients · 2023Review
- Low Overpotential Amperometric Sensor Using YbBiosensors · 2023Article
- Geographic variation in urinary tract and genital cancers in Iran: a hypothesis involving exposure to solar radiation.BMC research notes · 2023Article
- Vitamin E - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
- Association between Vitamin D Supplementation and Cancer Mortality: A Systematic Review and Meta-Analysis.Cancers · 2022Review
- Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study.BMC medicine · 2022Article
- The Association Between Vitamin C and Cancer: A Two-Sample Mendelian Randomization Study.Frontiers in genetics · 2022Article
- Global, regional and national burden of bladder cancer and its attributable risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease study 2019.BMJ global health · 2021Article
- Vitamin C Intake and Cancers: An Umbrella Review.Frontiers in nutrition · 2021Review
- Bladder cancer: total antioxidant capacity and pharmacotherapy with vitamin-E.International urology and nephrology · 2020Article
- Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols.Molecular carcinogenesis · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A dose-response meta-analysis was conducted to assess the association of vitamin C, D, E with risk of bladder cancer. Pertinent studies were identified in PubMed and Embase. The random-effect model was used. The relative risk (95% confidence interval) of bladder cancer was 0.99 (0.95-1.03) for every 100 IU/day increment in vitamin D from diet plus supplement and 0.95 (0.90-1.00) for every 10 nmol/L increment in circulating vitamin D. The effect for every 10 mg/day increment was 0.96 (0.90-1.02) for vitamin E from diet plus supplement, 0.83 (0.72-0.95) from diet and 0.88 (0.67-1.15) from supplement, and the effect was 0.84 (0.76-0.94) for every 1 mg/dL increment in circulating α-Tocopherol and 1.22 (1.00-1.49) for every 0.1 mg/dL increment in circulating γ-Tocopherol. The observed association for vitamin D and vitamin E was significant among smokers but not among non-smokers. No significant association was found between vitamin C and risk of bladder cancer in the dose-response analysis. Based on the dose-response analysis, the risk of bladder cancer might be inversely associated with vitamin D and E (especially α-Tocopherol), but positively associated with γ-Tocopherol.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.