ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)
The Implantable Pediatric Artificial Lung: Interim Report on the Development of an End-Stage Lung Failure Model.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Toward a Long-Term Artificial Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Review
- A Model of Pediatric End-Stage Lung Failure in Small Lambs <20 kg.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- Early in vivo experience with the pediatric continuous-flow total artificial heart.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
- Development of a Model of Pediatric Lung Failure Pathophysiology.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
- Pediatric Artificial Lung: A Low-Resistance Pumpless Artificial Lung Alleviates an Acute Lamb Model of Increased Right Ventricle Afterload.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
An implantable pediatric artificial lung (PAL) may serve as a bridge to lung transplantation for children with end-stage lung failure (ESLF); however, an animal model of pediatric lung failure is needed to evaluate the efficacy of PAL before it can enter clinical trials. The objective of this study was to assess ligation of the right pulmonary artery (rPA) as a model for pediatric ESLF. Seven lambs weighing 20-30 kg underwent rPA ligation and were recovered and monitored for up to 4 days. Intraoperatively, rPA ligation significantly increased physiologic dead space fraction (Vd/Vt; baseline = 48.6 ± 5.7%, rPA ligation = 60.1 ± 5.2%, p = 0.012), mean pulmonary arterial pressure (mPPA; baseline = 17.4 ± 2.2 mm Hg, rPA ligation = 28.5 ± 5.2 mm Hg, p < 0.001), and arterial partial pressure of carbon dioxide (baseline = 40.4 ± 9.3 mm Hg, rPA ligation = 57.3 ± 12.7 mm Hg, p = 0.026). Of the seven lambs, three were unable to be weaned from mechanical ventilation postoperatively, three were successfully weaned but suffered cardiorespiratory failure within 4 days, and one survived all 4 days. All four animals that were successfully weaned from mechanical ventilation had persistent pulmonary hypertension (mPPA = 28.6 ± 2.2 mm Hg) and remained tachypneic (respiratory rate = 63 ± 21 min). Three of the four recovered lambs required supplemental oxygen. We conclude that rPA ligation creates the physiologic derangements commonly seen in pediatric ESLF and may be suitable for testing and implanting a PAL.
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Registered trials
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