SynthesisPloS one2015
Hyponatremia improvement is associated with a reduced risk of mortality: evidence from a meta-analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04588207 (Urea for Chronic Hyponatremia), which is not on this map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urea for Chronic Hyponatremia: A Pilot Study
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Outcomes with Sodium Overcorrection in Chronic Hyponatremia: A Systematic Review and Meta-analysis.Journal of general internal medicine · 2026Pooled it
- Prevalence and Prognostic Significance of Hyponatremia in Patients With Lung Cancer: Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Impact of Vaptans on Clinical Outcomes in Cirrhosis Patients: A Meta-Analysis of Randomized Controlled Trials.Frontiers in pharmacology · 2019Pooled it
- Heat-associated hyponatremia and its outcomes in very old inpatients in northern Germany.Zeitschrift fur Gerontologie und Geriatrie · 2026Article
- Hyponatraemia in Neck of Femur Fracture: A Narrative Review of Epidemiology, Pathophysiology, and Outcomes.Geriatrics (Basel, Switzerland) · 2026Review
- Rising mortality from electrolyte and acid-base imbalances in the United States (1999-2020): a joinpoint regression analysis of national trends and disparities.Annals of medicine and surgery (2012) · 2026Review
- Eight-Year Retrospective Analysis of Mortality in Patients with Moderate to Severe Hyponatremia: A Comprehensive Study.Journal of clinical medicine · 2025Article
- Association Between Hyponatremia and Mortality and Readmission in Multimorbid Older Adults-A Cohort Study.Journal of clinical medicine · 2025Article
- Hyponatraemia in ageing.Nature reviews. Endocrinology · 2025Review
- Metabolic Signatures in Lung Cancer: Prognostic Value of Acid-Base Disruptions and Serum Indices.International journal of molecular sciences · 2025Article
- Effects of reduced extracellular sodium on proliferation and invasive activity of renal cell carcinoma cell lines.Scientific reports · 2025Article
- Correcting hyponatraemia is associated with improved survival in hyponatraemic metastatic cancer patients.Clinical kidney journal · 2025Article
- Impact of Hyponatraemia at Clinical Stable-State on Survival in Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Syndrome of inappropriate antidiuresis/hyponatremia in COVID-19.Pituitary · 2024Review
- Short-Term Outcomes of Patients With Hyponatremia Presenting to the Emergency Department: An Observational Study.Cureus · 2024Article
- Effects of Reduced Extracellular Sodium Concentrations on Cisplatin Treatment in Human Tumor Cells: The Role of Autophagy.International journal of molecular sciences · 2024Article
- Hyponatremia after COVID-19 is frequent in the first year and increases re-admissions.Scientific reports · 2024Observational
- Effects of correction rate for severe hyponatremia in the intensive care unit on patient outcomes.Journal of critical care · 2023Article
- Article
- Pituitary and SARS CoV-2: An unremitting conundrum.Best practice & research. Clinical endocrinology & metabolism · 2023Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyponatremia is the most common electrolyte disorder and it is associated with increased morbidity and mortality. However, there is no clear demonstration that the improvement of serum sodium concentration ([Na(+)]) counteracts the increased risk of mortality associated with hyponatremia. Thus, we performed a meta-analysis that included the published studies that addressed the effect of hyponatremia improvement on mortality. METHODS AND
findingsA Medline, Embase and Cochrane search was performed to retrieve all English-language studies of human subjects published up to June 30th 2014, using the following words: "hyponatremia", "hyponatraemia", "mortality", "morbidity" and "sodium". Fifteen studies satisfied inclusion criteria encompassing a total of 13,816 patients. The identification of relevant abstracts, the selection of studies and the subsequent data extraction were performed independently by two of the authors, and conflicts resolved by a third investigator. Across all fifteen studies, any improvement of hyponatremia was associated with a reduced risk of overall mortality (OR=0.57[0.40-0.81]). The association was even stronger when only those studies (n=8) reporting a threshold for serum [Na(+)] improvement to >130 mmol/L were considered (OR=0.51[0.31-0.86]). The reduced mortality rate persisted at follow-up (OR=0.55[0.36-0.84] at 12 months). Meta-regression analyses showed that the reduced mortality associated with hyponatremia improvement was more evident in older subjects and in those with lower serum [Na(+)] at enrollment.
conclusionsThis meta-analysis documents for the first time that improvement in serum [Na(+)] in hyponatremic patients is associated with a reduction of overall mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.