Trial reportGenetics in medicine : official journal of the American College of Medical Genetics2016
Does rapid genetic counseling and testing in newly diagnosed breast cancer patients cause additional psychosocial distress? results from a randomized clinical trial.
Trial report in Genetics in medicine : official journal of the American College of Medical Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Breast cancer patients' experiences and outcomes of mainstream genetic testing with and without genetic counseling.Future oncology (London, England) · 2026Article
- Quality of life, anxiety and cancer worry following hereditary cancer testing: a 6-month Swedish follow-up study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Beyond survival: psychoneuroimmunology-driven cancer psychological rehabilitation-a paradigm shift from symptom management to biobehavioral remodeling.Frontiers in oncology · 2026Review
- Investigation on the Anxiety and Depression Status of Thalassemia Carriers After Genetic Counseling.Neuropsychiatric disease and treatment · 2025Article
- The Clinical and Psychosocial Outcomes for Women Who Received Unexpected Clinically Actionable Germline Information Identified through Research: An Exploratory Sequential Mixed-Methods Comparative Study.Journal of personalized medicine · 2022Article
- Psychosocial impact of proactive rapid genetic counseling following breast cancer diagnosis.Psycho-oncology · 2022Article
- "It was an important part of my treatment": a qualitative study of Norwegian breast Cancer patients' experiences with mainstreamed genetic testing.Hereditary cancer in clinical practice · 2022Article
- Genetic testing in women with early-onset breast cancer: a Traceback pilot study.Breast cancer research and treatment · 2021Article
- Recontacting non-BRCA1/2 breast cancer patients for germline CHEK2 c.1100del pathogenic variant testing: uptake and patient experiences.Hereditary cancer in clinical practice · 2021Article
- Subjective Cognitive Concerns and Attitudes toward Genetic Testing Are Associated with Depressive Symptoms and Quality of Life after Genetic Testing for the Cerebral Cavernous Malformation Common Hispanic Mutation (CCM1).Journal of behavioral and brain science · 2020Article
- Patients' Views of Treatment-Focused Genetic Testing (TFGT): Some Lessons for the Mainstreaming of BRCA1 and BRCA2 Testing.Journal of genetic counseling · 2018Article
- Gaps in Receipt of Clinically Indicated Genetic Counseling After Diagnosis of Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Article
- Universal BRCA1/BRCA2 Testing for Ovarian Cancer Patients is Welcomed, but with Care: How Women and Staff Contextualize Experiences of Expanded Access.Journal of genetic counseling · 2017Article
- Risk Perception and Psychological Distress in Genetic Counselling for Hereditary Breast and/or Ovarian Cancer.Journal of genetic counseling · 2017Article
- Identifying Needs: a Qualitative Study of women's Experiences Regarding Rapid Genetic Testing for Hereditary Breast and Ovarian Cancer in the DNA BONus Study.Journal of genetic counseling · 2017Article
- Preoperative genetic testing impacts surgical decision making in BRCA mutation carriers with breast cancer: a retrospective cohort analysis.Hereditary cancer in clinical practice · 2017Article
- Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance.Familial cancer · 2017Article
- Breast Cancer Genetic Counseling: A Surgeon's Perspective.Frontiers in surgery · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 13 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFemale breast cancer patients carrying a BRCA1/2 mutation have an increased risk of second primary breast cancer. Rapid genetic counseling and testing (RGCT) before surgery may influence choice of primary surgical treatment. In this article, we report on the psychosocial impact of RGCT.
methodsNewly diagnosed breast cancer patients at risk for carrying a BRCA1/2 mutation were randomized to an intervention group (offer of RGCT) or a usual care control group (ratio 2:1). Psychosocial impact and quality of life were assessed with the Impact of Events Scale, Hospital Anxiety and Depression Scale, Cancer Worry Scale, and the EORTC QLQ-C30 and QLQ-BR23. Assessments took place at study entry and at 6- and 12-month follow-up visits.
resultsBetween 2008 and 2010, 265 patients were recruited into the study. Completeness of follow-up data was more than 90%. Of the 178 women in the intervention group, 177 had genetic counseling, of whom 71 (40%) had rapid DNA testing and 59 (33%) received test results before surgery. Intention-to-treat and per-protocol analyses showed no statistically significant differences between groups over time in any of the psychosocial outcomes.
conclusionsIn this study, RGCT in newly diagnosed breast cancer patients did not have any measurable adverse psychosocial effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.