Evidence map›Paper›PMID 25905035›Full record

ArticleFEBS open bio2015

Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways.

Tamaki Kurosawa, Atsushi Yamada, Masamichi Takami, Dai Suzuki, Yoshiro Saito, Katsuhiro Hiranuma, Takuya Enomoto, Naoko Morimura, Matsuo Yamamoto, Takehiko Iijima and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Role of Nephronectin in Pathophysiology of Silicosis.International journal of molecular sciences · 2019
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Tamaki KurosawaDepartment of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan ; Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, Shinagawa, Tokyo 142-8555, Japan.
Atsushi YamadaDepartment of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan.
Masamichi TakamiDepartment of Pharmacology, School of Dentistry, Showa University, Ohta, Tokyo 145-8515, Japan.
Dai SuzukiDepartment of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan.
Yoshiro SaitoDepartment of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan ; Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Ohta, Tokyo 145-8515, Japan.
Katsuhiro HiranumaDepartment of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan ; Department of Perioperative Medicine Division of Anesthesiology, School of Dentistry, Showa University, Ohta, Tokyo 145-8515, Japan.
Takuya EnomotoDepartment of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan ; Department of Periodontology, School of Dentistry, Showa University, Ohta, Tokyo 145-8515, Japan.
Naoko MorimuraBrain Science Laboratory, The Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Matsuo YamamotoDepartment of Periodontology, School of Dentistry, Showa University, Ohta, Tokyo 145-8515, Japan.
Takehiko IijimaDepartment of Perioperative Medicine Division of Anesthesiology, School of Dentistry, Showa University, Ohta, Tokyo 145-8515, Japan.
Tatsuo ShirotaDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Ohta, Tokyo 145-8515, Japan.
Hiroyuki ItabeDivision of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, Shinagawa, Tokyo 142-8555, Japan.
Ryutaro KamijoDepartment of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan.
Showa University · JPRitsumeikan University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nephronectin (Npnt), also called POEM, is an extracellular matrix protein considered to play critical roles as an adhesion molecule in the development and functions of various tissues, such as the kidneys, liver, and bones. In the present study, we examined the molecular mechanism of Npnt gene expression and found that oncostatin M (OSM) strongly inhibited Npnt mRNA expression in MC3T3-E1 cells from a mouse osteoblastic cell line. OSM also induced a decrease in Npnt expression in both time- and dose-dependent manners via both the JAK/STAT and MAPK pathways. In addition, OSM-induced inhibition of osteoblast differentiation was recovered by over-expression of Npnt. These results suggest that OSM inhibits Npnt expression via the JAK/STAT and MAPK pathways, while down-regulation of Npnt by OSM influences inhibition of osteoblast differentiation.

Indexed as

BMP-2, bone morphogenetic protein-2ERK, extracellular signal-regulated kinaseJAK, janus kinaseJAK/STATJNK, c-Jun N-terminal kinaseMAM, meprin, A5 protein, and receptor protein-tyrosine phosphatase μMAPKMAPK, mitogen-activated protein kinaseMEF2, myocyte enhancer-binding factor 2ANephronectinNpnt, nephronectinOncostatin MOSM, oncostatin MOSMR, OSM receptorSTAT, signal transducer and activator of transcriptionTGF-β, transforming growth factor-βTNF-α, tumor necrosis factor-α

Identifiers

PMID25905035
PMCPMC4404411
OpenAlexW2023871613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.