Evidence map›Paper›PMID 25905031›Full record

ArticleResults in immunology2015

Effective anthelmintic therapy of residents living in endemic area of high prevalence for Hookworm and Schistosoma mansoni infections enhances the levels of allergy risk factor anti-Der p1 IgE.

Sabrina S Campolina, Marcio S S Araujo, Tércia M R L Rezende, Leonardo Matoso, Humberto F O Quites, Andréa Teixeira-Carvalho, Olindo A Martins-Filho, Andrea Gazzinelli, Rodrigo Correa-Oliveira

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Results in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sabrina S CampolinaLaboratório de Imunologia Celular e Molecular, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
Marcio S S AraujoLaboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
Tércia M R L RezendeFaculdade de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Leonardo MatosoLaboratório de Imunologia Celular e Molecular, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
Humberto F O QuitesFaculdade de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Andréa Teixeira-CarvalhoLaboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
Olindo A Martins-FilhoLaboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
Andrea GazzinelliFaculdade de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil ; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Belo Horizonte, Minas Gerais, Brazil.
Rodrigo Correa-OliveiraLaboratório de Imunologia Celular e Molecular, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil ; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Belo Horizonte, Minas Gerais, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work were investigated the relationship between Hookworm/Schistosoma mansoni infections and allergy related risk factors in two endemic areas with distinct prevalence of infections and co-infection. The intensity of infections, eosinophilia, allergy risk factors, infections status and anti-Der p1 IgE levels before and 2 years (population 1) and 3 years (population 2) after anthelmintic treatment, were evaluated. It was observed that the population with lower prevalence and intensity of infection (population 2) had lower eosinophils counts (>600/mm(3)) and higher animal contact than the population with higher parasites intensity (population 1). After anthelmintic treatment the intensity of S. mansoni single infection decreased, but no changes were observed in Hookworm and co-infected individuals. The anthelmintic treatment also enhanced anti-Der p1 IgE optical density in ELISA on the subgroups that became negative for helminth infection regardless of their previous infection condition in population 1. Facing that, we evaluated the anti-Der p1 IgE reactivity index, and the ratio (after/before treatment) was significantly higher in patients co-infected before treatment. On the other hand, no association between anti-Der p1 IgE reactivity index and the intensity of infections were observed. In conclusion, effective anthelmintic therapy of subjects from endemic areas with high prevalence of Hookworm and S. mansoni infections enhances anti-Der p1 IgE levels.

Indexed as

Allergic disordersAllergy risk factorsAnti-Der p1 IgE

Identifiers

PMID25905031
PMCPMC4404415
OpenAlexW2057610871

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.