ReviewComputational and structural biotechnology journal2015
Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae.
Review in Computational and structural biotechnology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
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- PE-STAR: prime editing with SOS-triggered and RecJ-augmented repair enables high-efficiency editing in Escherichia coli.Nucleic acids research · 2026Article
- Epistasis mediates the role of negative frequency-dependent selection in bacterial strain structure.PLoS computational biology · 2026Article
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- Comparative Genotyping of Malaysian Clinical Isolates ofThe Malaysian journal of medical sciences : MJMS · 2025Article
- The Complex Landscape of Updated Pneumococcal Conjugate Vaccines.Open forum infectious diseases · 2025Article
- Molecular Targets inGenes · 2024Review
- Estimating geographical spread ofMicrobial genomics · 2024Article
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- High Prevalence of Novel Sequence Types inMicroorganisms · 2024Article
- Comparison of next generation technologies and bioinformatics pipelines for capsular typing ofJournal of clinical microbiology · 2023Article
- Adding context to the pneumococcal core genes using bioinformatic analysis of the intergenic pangenome ofFrontiers in bioinformatics · 2023Article
- Comment on: "Prevalence, Antibiotic Susceptibility Profile and Associated Factors of Group A Streptococcal Pharyngitis Among Pediatric Patients with Acute Pharyngitis in Gondar, Northwest Ethiopia" [Letter].Infection and drug resistance · 2023Article
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- PclR is a transcriptional activator of the gene that encodes the pneumococcal collagen-like protein PclA.Scientific reports · 2022Article
- Comparative analysis ofFrontiers in microbiology · 2022Article
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3 authors.
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Abstract
Streptococcus pneumoniae (the pneumococcus) is a highly recombinogenic bacterium responsible for a high burden of human disease globally. Genetic recombination, a process in which exogenous DNA is acquired and incorporated into its genome, is a key evolutionary mechanism employed by the pneumococcus to rapidly adapt to selective pressures. The rate at which the pneumococcus acquires genetic variation through recombination is much higher than the rate at which the organism acquires variation through spontaneous mutations. This higher rate of variation allows the pneumococcus to circumvent the host innate and adaptive immune responses, escape clinical interventions, including antibiotic therapy and vaccine introduction. The rapid influx of whole genome sequence (WGS) data and the advent of novel analysis methods and powerful computational tools for population genetics and evolution studies has transformed our understanding of how genetic recombination drives pneumococcal adaptation and evolution. Here we discuss how genetic recombination has impacted upon the evolution of the pneumococcus.
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