Evidence map›Paper›PMID 25904960›Full record

ArticleJournal of family & reproductive health2015

Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses.

Elham Azimi Nekoo, Maryam Chamani, Ensieh Shahrokh Tehrani, Batool Hossein Rashidi, Fatemeh Davari Tanha, Vahid Kalantari

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of family & reproductive health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03353883 (Is Early Preparation With GnRh Agonists Injection on D-1 of Menses of Hormonal Replacement Cycle Improves Pregnancy Rate in Women With Impaired Ovulation and Undergoing Frozen-Thawed Embryo Transfer? A Randomized Controlled Study), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03353883 phase2 / phase3unknown statusnot on this mapstarted 2017, after this paper: background citation

Is Early Preparation With GnRh Agonists Injection on D-1 of Menses of Hormonal Replacement Cycle Improves Pregnancy Rate in Women With Impaired Ovulation and Undergoing Frozen-Thawed Embryo Transfer? A Randomized Controlled Study

TypeinterventionalSponsorBenha UniversityRan2017 to 2018Enrolled200ConditionsInfertility, FemaleArmsTriptorelin SR
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Cycle regimens for endometrial preparation prior to frozen embryo transfer.The Cochrane database of systematic reviews · 2025
    Pooled it
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  3. Cycle regimens for frozen-thawed embryo transfer.The Cochrane database of systematic reviews · 2017
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  19. Methods for endometrial preparation in frozen-thawed embryo transfer cycles.Journal of the Turkish German Gynecological Association · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elham Azimi NekooTehran University of Medical Sciences, Tehran, Iran.
Maryam ChamaniTehran University of Medical Sciences, Tehran, Iran.
Ensieh Shahrokh TehraniReproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Batool Hossein RashidiReproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh Davari TanhaWomen's hospital, Tehran University of Medical Sciences, Tehran, Iran.
Vahid KalantariSt Maarten School of Medicine, American University of Integrative Sciences, Cole Bay, St. Maarten.
Tehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the reproductive outcome of artificial endometrial preparation with exogenous steroids for frozen-thawed embryo transfer with and without pre-treatment with depot gonadotropin releasing hormone agonist (GnRH-a) in women with regular menses. MATERIALS AND

methodsThis is a prospective randomized clinical trial conducted in two ART centers on 176 women undergoing frozen-thawed embryo transfer. All patients received oral estradiol valerate 4 mg daily from day 2 to day 5 and 6 mg per day from day 6 to the day of the pregnancy test. In day 13 of cycle, an ultrasound examination was performed. After ultrasound confirmation of endometrial thickness (≥8 mm) and no ovarian activity, progesterone in cyclogest supp (800 mg daily) was added. The dose of estradiol would be increased to 8 mg per day if the endometrial thickness was less than 8mm. Two or 3 embryos were transferred via transcervical route 48 hours after the beginning of progesterone administration. In group A (93 patients), Difereline (3.75 mg Im), as a depot GnRH agonist was administered in the midluteal phase (day 21) of previous cycle. In the other group B (n = 83) steroid supplementation was commenced without prior pituitary suppression. Chemical and clinical pregnancy rates were compared in two groups.

resultsNo significant differences were seen between two groups in terms of chemical pregnancy and clinical pregnancy rates.

conclusionThe findings support the artificial protocol without any pretreatment suppressive drugs to reduce the adverse side effects of GnRH agonists also to minimize the costs.

Indexed as

frozen-thawed embryo transfer; GnRH agonist; artificial cycle; endometrial preparation; pregnancy outcome

Identifiers

PMID25904960
PMCPMC4405510
OpenAlexW1920708658

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.