ArticleInternational journal of pediatric endocrinology2015
Adiponectin/resistin levels and insulin resistance in children: a four country comparison study.
Article in International journal of pediatric endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05701813 (Effects of Inositols on Insulin Resistance in Children With Obesity), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Inositols on Insulin Resistance in Children With Obesity (ONIRICO Trial)
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Relationship between adiponectin and blood pressure in obese Latino adolescent boys with a family history of type 2 diabetes.BMC pediatrics · 2023Article
- Obesity-induced ocular changes in children and adolescents: A review.Frontiers in pediatrics · 2023Review
- Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican ChildrenJournal of clinical research in pediatric endocrinology · 2020Article
- Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction.Nutrients · 2020Article
- Myokine-adipokine cross-talk: potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome.Diabetology & metabolic syndrome · 2019Article
- Minor diplotypes of FMO3 might protect children and adolescents from obesity and insulin resistance.International journal of obesity (2005) · 2018Article
- Childhood obesity classification systems and cardiometabolic risk factors: a comparison of the Italian, World Health Organization and International Obesity Task Force references.Italian journal of pediatrics · 2017Article
- Cinnamon effects on metabolic syndrome: a review based on its mechanisms.Iranian journal of basic medical sciences · 2016Review
- From Placenta to Polycystic Ovarian Syndrome: The Role of Adipokines.Mediators of inflammation · 2016Review
- Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundThere are few reports on the effects of ethnicity or gender in the association between adipocytokines and insulin resistance in children of different ages. This study assessed associations between serum concentrations of adiponectin/resistin and parameters of insulin resistance in children from 4 different countries.
methodsA total of 2,290 children were analyzed in this study; each was from one of 4 different countries (Japan, Thailand, Italy and USA), and grouped according to age (8-11 years old in Group 1 and 12-15 years old in Group 2).
resultsAdioponectin was higher in female than in male children, and in Group 1 than in Group 2. Generally, adiponectin was lower in Asian as compared to Italian and American children. These tendencies remained even after adjustment for body mass index (BMI) or waist circumstance (WC). Among older children (Group 2), resistin was higher in female than in male children. Significant correlations by non-parametric univariate correlation coefficients and Spearman's rank correlation coefficients were found between adiponectin and homeostasis model assessment of insulin resistance (HOMA-IR), and fasting serum insulin levels in young Japanese, Italian, and American female children(p < 0.01, p < 0.05, p < 0.05, respectively). Correlations between serum adiponectin and HOMA-IR were also found among older male Italian, American, and Thai children (p < 0.05, p < 0.001, p < 0.001, respectively). In multiple regression analysis by forced entry method, adiponectin correlated with HOMA-IR in Italian and American male children, and in all older female children regardless of country of origin. There was no correlation between resistin and markers of insulin resistance in children from any of the countries.
conclusionsWe conclude that serum adiponectin concentrations are lower in Asian as compared to Italian and American children, and that adiponectin but not resistin contributes to differences in markers for insulin resistance in children from different populations.
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