ReviewFrontiers in plant science2015
Considerations for designing chemical screening strategies in plant biology.
Review in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- High-throughput screening and structure-guided design of small molecules enable modulation of SAL-PAP stress signaling.Journal of experimental botany · 2026Article
- High-throughput screening for biostimulant discovery: opportunities to enhance nitrogen use efficiency.Frontiers in plant science · 2026Review
- Triphenylphosphonium is an effective targeting moiety for plant mitochondria.The New phytologist · 2025Article
- Arabidopsis as a model for translational research.The Plant cell · 2025Review
- Chemical application improves stress resilience in plants.Plant molecular biology · 2025Review
- Small chemical molecules regulating the phytohormone signalling alter the plant's physiological processes to improve stress adaptation, growth and productivity.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- A machine learning enhanced EMS mutagenesis probability map for efficient identification of causal mutations in Caenorhabditis elegans.PLoS genetics · 2024Article
- Methylated Biochemical Fulvic Acid-Derived Hydrogels with Improved Swelling Behavior and Water Retention Capacity.Materials (Basel, Switzerland) · 2024Article
- Inhibition of a conserved bacterial dual-specificity phosphatase confers plant tolerance toiScience · 2024Article
- Novel inhibitors of microtubule organization and phragmoplast formation in diverse plant species.Life science alliance · 2023Article
- SMART v1.0: A Database for Small Molecules with Functional Implications in Plants.Interdisciplinary sciences, computational life sciences · 2022Article
- Identification of stomatal-regulating molecules from de novo arylamine collection through aromatic C-H amination.Scientific reports · 2022Article
- Experimental and conceptual approaches to root water transport.Plant and soil · 2022Review
- A small molecule antagonizes jasmonic acid perception and auxin responses in vascular and nonvascular plants.Plant physiology · 2021Article
- Plant hairy roots enable high throughput identification of antimicrobials against Candidatus Liberibacter spp.Nature communications · 2020Article
- Inhibition of jasmonate-mediated plant defences by the fungal metabolite higginsianin B.Journal of experimental botany · 2020Article
- Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana.Journal of visualized experiments : JoVE · 2018Article
- Robust Microplate-Based Methods for Culturing andFrontiers in plant science · 2018Article
- Plant Chemical Genetics: From Phenotype-Based Screens to Synthetic Biology.Plant physiology · 2017Review
- A plant-based chemical genomics screen for the identification of flowering inducers.Plant methods · 2017Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditionally, biologists regularly used classical genetic approaches to characterize and dissect plant processes. However, this strategy is often impaired by redundancy, lethality or pleiotropy of gene functions, which prevent the isolation of viable mutants. The chemical genetic approach has been recognized as an alternative experimental strategy, which has the potential to circumvent these problems. It relies on the capacity of small molecules to modify biological processes by specific binding to protein target(s), thereby conditionally modifying protein function(s), which phenotypically resemble mutation(s) of the encoding gene(s). A successful chemical screening campaign comprises three equally important elements: (1) a reliable, robust, and quantitative bioassay, which allows to distinguish between potent and less potent compounds, (2) a rigorous validation process for candidate compounds to establish their selectivity, and (3) an experimental strategy for elucidating a compound's mode of action and molecular target. In this review we will discuss details of this general strategy and additional aspects that deserve consideration in order to take full advantage of the power provided by the chemical approach to plant biology. In addition, we will highlight some success stories of recent chemical screenings in plant systems, which may serve as teaching examples for the implementation of future chemical biology projects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.