ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- GABAFrontiers in neural circuits · 2022Pooled it
- Electrophysiologically Targeted Biopsies Reveal the Transcriptional Landscape of Focal Epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons.bioRxiv : the preprint server for biology · 2026Article
- Cathodal weak direct current decreases epileptic excitability with reduced neuronal activity and enhanced delta oscillations.The Journal of physiology · 2025Article
- Modulation ofCurrent neuropharmacology · 2025Article
- Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission.Acta pharmacologica Sinica · 2024Article
- Transient Seizure Clusters and Epileptiform Activity Following Widespread Bilateral Hippocampal Interneuron Ablation.eNeuro · 2024Article
- Ictal activity is sustained by the estrogen receptor β during the estrous cycle.Current research in neurobiology · 2024Article
- Cell-type specific and multiscale dynamics of human focal seizures in limbic structures.Brain : a journal of neurology · 2023Article
- Chronic intracranial recordings after resection for epilepsy reveal a "running down" of epileptiform activity.Epilepsia · 2023Article
- Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network.Current biology : CB · 2023Article
- Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal CortexThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Focal seizures are organized by feedback between neural activity and ion concentration changes.eLife · 2022Article
- Seizures initiate in zones of relative hyperexcitation in a zebrafish epilepsy model.Brain : a journal of neurology · 2022Article
- The metabolic basis of epilepsy.Nature reviews. Neurology · 2022Review
- Ictogenesis? That's Random…..Epilepsy currents · 2022Article
- In vitro ictogenesis is stochastic at the single neuron level.Brain : a journal of neurology · 2022Article
- Disrupting Epileptiform Activity by Preventing Parvalbumin Interneuron Depolarization Block.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- In Vivo Microelectrode Arrays for Detecting Multi-Region Epileptic Activities in the Hippocampus in the Latent Period of Rat Model of Temporal Lobe Epilepsy.Micromachines · 2021Article
- Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP.Epilepsy currents · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
Mechanisms of seizure initiation are unclear. To evaluate the possible roles of inhibitory neurons, unit recordings were obtained in the dentate gyrus, CA3, CA1, and subiculum of epileptic pilocarpine-treated rats as they experienced spontaneous seizures. Most interneurons in the dentate gyrus, CA1, and subiculum increased their firing rate before seizures, and did so with significant consistency from seizure to seizure. Identification of CA1 interneuron subtypes based on firing characteristics during theta and sharp waves suggested that a parvalbumin-positive basket cell and putative bistratified cells, but not oriens lacunosum moleculare cells, were activated preictally. Preictal changes occurred much earlier than those described by most previous in vitro studies. Preictal activation of interneurons began earliest (>4 min before seizure onset), increased most, was most prevalent in the subiculum, and was minimal in CA3. Preictal inactivation of interneurons was most common in CA1 (27% of interneurons) and included a putative ivy cell and parvalbumin-positive basket cell. Increased or decreased preictal activity correlated with whether interneurons fired faster or slower, respectively, during theta activity. Theta waves were more likely to occur before seizure onset, and increased preictal firing of subicular interneurons correlated with theta activity. Preictal changes by other hippocampal interneurons were largely independent of theta waves. Within seconds of seizure onset, many interneurons displayed a brief pause in firing and a later, longer drop that was associated with reduced action potential amplitude. These findings suggest that many interneurons inactivate during seizures, most increase their activity preictally, but some fail to do so at the critical time before seizure onset.
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