ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Injection of a dopamine type 2 receptor antagonist into the dorsal striatum disrupts choices driven by previous outcomes, but not perceptual inference.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour.Nature communications · 2025Trial
- The impact of aripiprazole on neurocognitive function in individuals at clinical high risk for psychosis: A comparison with olanzapine and non-antipsychotic treatment.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Dopamine and Norepinephrine Differentially Mediate the Exploration-Exploitation Tradeoff.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Motor System-Dependent Effects of Amygdala and Ventral Striatum Lesions on Explore-Exploit Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Attractor dynamics reflect decision confidence in macaque prefrontal cortex.Nature neuroscience · 2023Article
- The motivational role of the ventral striatum and amygdala in learning from gains and losses.Behavioral neuroscience · 2023Article
- Blocking D2/D3 dopamine receptors in male participants increases volatility of beliefs when learning to trust others.Nature communications · 2023Article
- Article
- Activation, but not inhibition, of the indirect pathway disrupts choice rejection in a freely moving, multiple-choice foraging task.Cell reports · 2022Article
- Everything is connected: Inference and attractors in delusions.Schizophrenia research · 2022Article
- Reinforcement-learning in fronto-striatal circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Impulsivity and risk-seeking as Bayesian inference under dopaminergic control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Inference as a fundamental process in behavior.Current opinion in behavioral sciences · 2021Article
- Rational inattention and tonic dopamine.PLoS computational biology · 2021Article
- Effects of Amygdala Lesions on Object-Based Versus Action-Based Learning in Macaques.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Attention-related modulation of caudate neurons depends on superior colliculus activity.eLife · 2020Article
- Hypothalamic Interactions with Large-Scale Neural Circuits Underlying Reinforcement Learning and Motivated Behavior.Trends in neurosciences · 2020Review
- Article
- Variability in Action Selection Relates to Striatal Dopamine 2/3 Receptor Availability in Humans: A PET Neuroimaging Study Using Reinforcement Learning and Active Inference Models.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Dimensionality, information and learning in prefrontal cortex.PLoS computational biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Decisions are often driven by a combination of immediate perception and previous experience. In this study, we investigated how these two sources of information are integrated and the neural systems that mediate this process. Specifically, we injected a dopamine type 1 antagonist (D1A; SCH23390) or a dopamine type 2 antagonist (D2A; eticlopride) into the dorsal striatum while macaques performed a task in which their choices were driven by perceptual inference and/or reinforcement of past choices. We found that the D2A affected choices based on previous outcomes. However, there were no effects of the D2A on choices driven by perceptual inference. We found that the D1A did not affect perceptual inference or reinforcement learning. Finally, a Bayesian model applied to the results suggested that the D2A may be increasing noise in the striatal representation of value, perhaps by disrupting the striatal population that normally represents value.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.