ArticleClinical cancer research : an official journal of the American Association for Cancer Research2015
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Unraveling the Role of the Microbiota in Cancer Immunotherapy: A New Frontier.Research (Washington, D.C.) · 2025Review
- PD-1 limits differentiation and plasticity of Tc17 cells.Frontiers in immunology · 2023Article
- Adoptive transfer of IL-4 reprogrammed Tc17 cells elicits anti-tumour immunity through functional plasticity.Immunology · 2022Article
- Effects of Chemotherapy on Neuroinflammation, Neuronal Damage, Neurogenesis, and Behavioral Performance in Bone Marrow Transplantation Recipient Mice.Neurotoxicity research · 2022Article
- IL12 integrated into the CAR exodomain converts CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation.Cancer biology & medicine · 2021Review
- IL6 Fuels Durable Memory for Th17 Cell-Mediated Responses to Tumors.Cancer research · 2020Article
- Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response.The Journal of clinical investigation · 2020Article
- Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation.Frontiers in immunology · 2019Article
- Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12.JCI insight · 2018Article
- Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity.Frontiers in immunology · 2018Review
- Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis.Cancer immunology, immunotherapy : CII · 2017Article
- Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.JCI insight · 2017Article
- Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic.Cancer immunology, immunotherapy : CII · 2016Review
- Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning.Journal for immunotherapy of cancer · 2016Article
- CAR T Cell Therapy: A Game Changer in Cancer Treatment.Journal of immunology research · 2016Review
- Harnessing the Microbiome to Enhance Cancer Immunotherapy.Journal of immunology research · 2015Review
- The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs.OncoimmunologyArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe adoptive cell transfer (ACT) of CD8(+) T cells is a promising treatment for advanced malignancies. Lymphodepletion before ACT enhances IFNγ(+)CD8(+) T cell (Tc0)-mediated tumor regression. Yet, how lymphodepletion regulates the function and antitumor activity of IL17A(+)CD8(+) T cells (Tc17) is unknown. EXPERIMENTAL
designTo address this question, pmel-1 CD8(+) T cells were polarized to secrete either IL17A or IFNγ. These subsets were then infused into mice with B16F10 melanoma that were lymphoreplete [no total body irradiation (TBI)], or lymphodepleted with nonmyeloablative (5 Gy) or myeloablative (9 Gy with hematopoietic stem cell transplantation) TBI. The activation of innate immune cells and function of donor T-cell subsets were monitored in recipient mice.
resultsTc17 cells regress melanoma in myeloablated mice to a greater extent than in lymphoreplete or nonmyeloablated mice. TBI induced functional plasticity in Tc17 cells, causing conversion from IL17A to IFNγ producers. Additional investigation revealed that Tc17 plasticity and antitumor activity were mediated by IL12 secreted by irradiated host dendritic cells (DC). Neutralization of endogenous IL12 reduced the antitumor activity of Tc17 cells in myeloablated mice, whereas ex vivo priming with IL12 enhanced their capacity to regress melanoma in nonmyeloablated animals. This, coupled with exogenous administration of low-dose IL12, obviated the need for host preconditioning, creating curative responses in nonirradiated mice.
conclusionsOur findings indicate that TBI-induced IL12 augments Tc17 cell-mediated tumor immunity and underline the substantial implications of in vitro preparation of antitumor Tc17 cells with IL12 in the design of T-cell immunotherapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.