ReviewSchizophrenia bulletin2015
Perinatal Risks and Childhood Premorbid Indicators of Later Psychosis: Next Steps for Early Psychosocial Interventions.
Review in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 104 citations in OpenAlex.
- Wellbeing and resilience: mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring--The WARM Study.BMC psychiatry · 2015Trial
- Clues from dyadic interactions in early childhood predict psychotic-like experiences at the transition to adolescence in a sample enriched for psychopathology risk.Journal of psychopathology and clinical science · 2025Article
- Perinatal insult dimensions and developmental trajectories of psychotic-like experiences.Schizophrenia (Heidelberg, Germany) · 2025Article
- Dimensions of perinatal and childhood adversities both merge and remain distinct.Child abuse & neglect · 2025Article
- Hair cortisol concentrations in pregnant women with bipolar, depressive, or schizophrenic spectrum disorders.Archives of women's mental health · 2024Article
- Adult human neurogenesis: A view from two schools of thought.IBRO neuroscience reports · 2023Review
- Premorbid adjustment associates with cognitive and functional deficits in individuals at ultra-high risk of psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Overlap and Mutual Distinctions Between Clinical Recovery and Personal Recovery in People With Schizophrenia in a One-Year Study.Schizophrenia bulletin · 2022Article
- Association Between Early Risk Factors and Level of Functioning at Age Seven in Children at Familial Risk for Schizophrenia Or Bipolar Disorder - the Danish High Risk and Resilience Study VIA 7.Scandinavian journal of child and adolescent psychiatry and psychology · 2022Article
- Accumulation of Disadvantages Across Multiple Domains Amongst Subgroups of Children of Parents With Schizophrenia or Bipolar Disorder: Clustering Data from the Danish High Risk and Resilience Study VIA 7.Schizophrenia bulletin open · 2022Article
- Antipsychotics during pregnancy and increased risk of congenital malformation in offspring: toward a systematic use of real-world data.The Lancet regional health. Europe · 2021Article
- Neurocognition in Kenyan youth at clinical high risk for psychosis.Schizophrenia research. Cognition · 2021Article
- Comprehensive characterization of motor and coordination functions in three adolescent wild-type mouse strains.Scientific reports · 2021Article
- Placental genomic risk scores and early neurodevelopmental outcomes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis.Frontiers in psychiatry · 2021Article
- Functional connectome organization predicts conversion to psychosis in clinical high-risk youth from the SHARP program.Molecular psychiatry · 2020Article
- Maternal Effects as Causes of Risk for Obsessive-Compulsive Disorder.Biological psychiatry · 2020Article
- Early childhood social communication deficits in youth at clinical high-risk for psychosis: Associations with functioning and risk.Development and psychopathology · 2020Article
- Altered resting-state functional connectivity in young children at familial high risk for psychotic illness: A preliminary study.Schizophrenia research · 2020Article
- Children of Patients Undergoing Psychiatric Treatment: An Investigation of Statutory Support Services After Referrals to Child Protection Services.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Schizophrenia and affective psychoses are debilitating disorders that together affect 2%-3% of the adult population. Approximately 50%-70% of the offspring of parents with schizophrenia manifest a range of observable difficulties including socioemotional, cognitive, neuromotor, speech-language problems, and psychopathology, and roughly 10% will develop psychosis. Despite the voluminous work on premorbid vulnerabilities to psychosis, especially on schizophrenia, the work on premorbid intervention approaches is scarce. While later interventions during the clinical high-risk (CHR) phase of psychosis, characterized primarily by attenuated positive symptoms, are promising, the CHR period is a relatively late phase of developmental derailment. This article reviews and proposes potential targets for psychosocial interventions during the premorbid period, complementing biological interventions described by others in this Special Theme issue. Beginning with pregnancy, parents with psychoses may benefit from enhanced prenatal care, social support, parenting skills, reduction of symptoms, and programs that are family-centered. For children at risk, we propose preemptive early intervention and cognitive remediation. Empirical research is needed to evaluate these interventions for parents and determine whether interventions for parents and children positively influence the developmental course of the offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.