ArticleJournal of neurophysiology2015
Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- Estimation of persistent inward currents contribution to inspiratory motoneuron firing in humans.The Journal of physiology · 2026Article
- Reverse engineering of motor unit discharge in multiple sclerosis reveals heterogeneity of voluntary motor commands.medRxiv : the preprint server for health sciences · 2026Article
- Motor unit discharge properties are modestly influenced by menstrual cycle-related fluctuations in sex hormone concentrations.bioRxiv : the preprint server for biology · 2026Article
- Analysis of motor units with high-density surface electromyography: methodological considerations and physiological significance.European journal of applied physiology · 2026Review
- Pathophysiology of voluntary motor commands at the level of the spinal motoneuron in patients with multiple sclerosis.medRxiv : the preprint server for health sciences · 2025Article
- Multiple patterns of persistent inward currents with multiple types of repetitive firings in medullary serotonergic neurons of mice: An experimental and modeling study.PLoS computational biology · 2025Article
- Intrinsic properties of spinal motoneurons degrade ankle torque control in humans.The Journal of physiology · 2025Article
- Age-related increase in the excitability of mouse layer V pyramidal neurons in the primary motor cortex is accompanied by an increased persistent inward current.GeroScience · 2025Article
- Higher dominant muscle strength is mediated by motor unit discharge rates and proportion of common synaptic inputs.Scientific reports · 2025Article
- Article
- Motoneuron persistent inward current contribution to increased torque responses to wide-pulse high-frequency neuromuscular electrical stimulation.European journal of applied physiology · 2024Article
- Relationships among motor unit discharge parameters used to estimate synaptic inputs to motoneurons.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Blood flow restriction increases necessary muscle excitation of the elbow flexors during a single high-load contraction.European journal of applied physiology · 2024Article
- Motor unit firing rate modulation is more impaired during flexion synergy-driven contractions of the biceps brachii in chronic stroke.medRxiv : the preprint server for health sciences · 2023Article
- A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on individual motor unit discharge patterns.Journal of neural engineering · 2023Article
- Effects of reciprocal inhibition and whole-body relaxation on persistent inward currents estimated by two different methods.The Journal of physiology · 2022Article
- Electrical Properties of Adult Mammalian Motoneurons.Advances in neurobiology · 2022Article
- The effects of membrane potential oscillations on the excitability of rat hypoglossal motoneurons.Frontiers in physiology · 2022Article
- Locomotor Pattern and Force Generation Modulated by Ionic Channels: A Computational Study of Spinal Networks Underlying Locomotion.Frontiers in computational neuroscience · 2022Article
- The Cellular Basis for the Generation of Firing Patterns in Human Motor Units.Advances in neurobiology · 2022Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Motoneuron activity is strongly influenced by the activation of persistent inward currents (PICs) mediated by voltage-gated sodium and calcium channels. However, the amount of PIC contribution to the activation of human motoneurons can only be estimated indirectly. Simultaneous recordings of pairs of motor units have been used to provide an estimate of the PIC contribution by using the firing rate of the lower threshold unit to provide an estimate of the common synaptic drive to both units, and the difference in firing rate (ΔF) of this lower threshold unit at recruitment and de-recruitment of the higher threshold unit to estimate the PIC contribution to activation of the higher threshold unit. It has recently been suggested that a number of factors other than PIC can contribute to ΔF values, including mechanisms underlying spike frequency adaptation and spike threshold accommodation. In the present study, we used a set of compartmental models representing a sample of 20 motoneurons with a range of thresholds to investigate how several different intrinsic motoneuron properties can potentially contribute to variations in ΔF values. We drove the models with linearly increasing and decreasing noisy conductance commands of different rate of rise and duration and determined the influence of different intrinsic mechanisms on discharge hysteresis (the difference in excitatory drive at recruitment and de-recruitment) and ΔF. Our results indicate that, although other factors can contribute, variations in discharge hysteresis and ΔF values primarily reflect the contribution of dendritic PICs to motoneuron activation.
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