Evidence map›Paper›PMID 25904687›Full record

ArticleNeurology2015

Occupational attainment influences survival in autopsy-confirmed frontotemporal degeneration.

Lauren Massimo, Jarcy Zee, Sharon X Xie, Corey T McMillan, Katya Rascovsky, David J Irwin, Ann Kolanowski, Murray Grossman

Abstract read
In one paragraph

Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Primary Progressive Aphasia and Stroke Aphasia.Continuum (Minneapolis, Minn.) · 2018
    Review
  15. Linguistic Aspects of Primary Progressive Aphasia.Annual review of linguistics · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lauren MassimoFrom the Frontotemporal Degeneration Center, Department of Neurology (L.M., C.T.M., K.R., D.J.I., M.G.), and Department of Biostatistics and Epidemiology (J.Z., S.X.X.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and The Pennsylvania State University (L.M., A.K.), College of Nursing, University Park, PA. massimol@uphs.upenn.edu.
Jarcy ZeeFrom the Frontotemporal Degeneration Center, Department of Neurology (L.M., C.T.M., K.R., D.J.I., M.G.), and Department of Biostatistics and Epidemiology (J.Z., S.X.X.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and The Pennsylvania State University (L.M., A.K.), College of Nursing, University Park, PA.
Sharon X XieFrom the Frontotemporal Degeneration Center, Department of Neurology (L.M., C.T.M., K.R., D.J.I., M.G.), and Department of Biostatistics and Epidemiology (J.Z., S.X.X.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and The Pennsylvania State University (L.M., A.K.), College of Nursing, University Park, PA.
Corey T McMillanFrom the Frontotemporal Degeneration Center, Department of Neurology (L.M., C.T.M., K.R., D.J.I., M.G.), and Department of Biostatistics and Epidemiology (J.Z., S.X.X.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and The Pennsylvania State University (L.M., A.K.), College of Nursing, University Park, PA.
Katya RascovskyFrom the Frontotemporal Degeneration Center, Department of Neurology (L.M., C.T.M., K.R., D.J.I., M.G.), and Department of Biostatistics and Epidemiology (J.Z., S.X.X.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and The Pennsylvania State University (L.M., A.K.), College of Nursing, University Park, PA.
David J IrwinFrom the Frontotemporal Degeneration Center, Department of Neurology (L.M., C.T.M., K.R., D.J.I., M.G.), and Department of Biostatistics and Epidemiology (J.Z., S.X.X.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and The Pennsylvania State University (L.M., A.K.), College of Nursing, University Park, PA.
Ann KolanowskiFrom the Frontotemporal Degeneration Center, Department of Neurology (L.M., C.T.M., K.R., D.J.I., M.G.), and Department of Biostatistics and Epidemiology (J.Z., S.X.X.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and The Pennsylvania State University (L.M., A.K.), College of Nursing, University Park, PA.
Murray GrossmanFrom the Frontotemporal Degeneration Center, Department of Neurology (L.M., C.T.M., K.R., D.J.I., M.G.), and Department of Biostatistics and Epidemiology (J.Z., S.X.X.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and The Pennsylvania State University (L.M., A.K.), College of Nursing, University Park, PA.

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1M
Project IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9M
Neural Basis of Generalized QuantifiersR01NS044266 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GROSSMAN, MURRAY · 2004 to 2014
$6.8M
CONCEPTUAL PROCESSING IN ALZHEIMERS DISEASER01AG015116 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GROSSMAN, MURRAY · 1998 to 2010
$4.3M
Identification of Endophenotypes in the Behavioral-Variant of Frontotemporal DemeK23NS088341 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI IRWIN, DAVID JOHN · 2014 to 2018
$836k
Multimodal Biomarkers in Frontotemporal Lobar DegenerationK01AG043503 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MCMILLAN, COREY T · 2013 to 2017
$642k
The Neural Basis of Apathy in Frontotemporal Degeneration: A Longitudinal StudyF32NR014777 · NINR · PENNSYLVANIA STATE UNIVERSITY, THE · PI MASSIMO, LAUREN M · 2013 to 2016
$144k
NIA NIH HHS AG010124NIA NIH HHS AG015116NIA NIH HHS AG017586NIA NIH HHS AG043503NIA NIH HHS K01 AG043503NIA NIH HHS P01 AG017586NIA NIH HHS P30 AG010124NIA NIH HHS R01 AG015116NINDS NIH HHS K23 NS088341NINDS NIH HHS NS044266NINDS NIH HHS NS053488NINDS NIH HHS P50 NS053488NINDS NIH HHS R01 NS044266NINR NIH HHS F32 NR014777NINR NIH HHS F32NR014777
6 · The paper itself

Abstract

objectiveTo examine the influence of occupational attainment and education on survival in autopsy-confirmed cases of frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD).

methodsWe performed a retrospective chart review of 83 demographically matched, autopsy-confirmed FTLD (n = 34) and AD (n = 49) cases. Each patient's primary occupation was classified and ranked. Level of education was recorded in years. Survival was defined as time from symptom onset until death. Linear regression was used to test for associations among occupational attainment, education, and patient survival.

resultsMedian survival was 81 months for FTLD and 95 months for AD. Years of education and occupational attainment were similar for both groups. We found that higher occupational attainment was associated with longer survival in FTLD but not AD.

conclusionsOur findings suggest that higher occupational attainment is associated with longer survival in autopsy-confirmed FTLD. The identification of protective factors associated with FTLD survival has important implications for estimates of prognosis and longitudinal studies such as treatment trials.

Indexed as

AgedAlzheimer DiseaseEducational StatusFemaleFrontotemporal Lobar DegenerationHumansMaleProportional Hazards ModelsRetrospective StudiesSocioeconomic Factors

Identifiers

PMID25904687
PMCPMC4442102

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.