Evidence map›Paper›PMID 25904651›Full record

ArticleAmerican journal of hypertension2016

Autophagy Portends the Level of Cardiac Hypertrophy in Experimental Hypertensive Swine Model.

Xin Zhang, Matthew E Gibson, Zi-Lun Li, Xiang-Yang Zhu, Kyra L Jordan, Amir Lerman, Lilach O Lerman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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  11. Progression of thanatophagy in cadaver brain and heart tissues.Biochemistry and biophysics reports · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Xin ZhangDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA;
Matthew E GibsonDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA;
Zi-Lun LiDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA; Division of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;
Xiang-Yang ZhuDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA;
Kyra L JordanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA;
Amir LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA;
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. lerman.lilach@mayo.edu.
Mayo Clinic · US

Funding

CT imaging for the assessment of kidney injury distal to renal artery stenosisR01DK073608 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2006 to 2015
$3.1M
Ultrasound Shockwave Therapy for Post-Stenotic Microvascular RemodelingR01HL123160 · NHLBI · MAYO CLINIC ROCHESTER · PI LERMAN, AMIR, LERMAN, LILACH O · 2015 to 2018
$3.0M
CT Evaluation of the Myocardial Effects of Risk FactorsR01HL077131 · NHLBI · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2004 to 2013
$2.8M
MSC-derived microvesicles in metabolic syndrome and renovascular diseaseR01DK102325 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2015 to 2018
$2.8M
EXTRAMURAL RES FACIL IMPROVEMENT PROG: POLYCYSTIC KIDNEY DISEASE, RENAL STUDIES,C06RR018898 · NCRR · MAYO CLINIC · PI BURNETT, JOHN C · 2004 to 2004
$2.3M
Noninvasive assessment of renal fibrosis using magnetization transfer MRIU01DK104273 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2014 to 2018
$1.8M
Low-Energy Shockwave Treatment Distal To Peripheral Vascular DiseaseR21HL121561 · NHLBI · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2014 to 2015
$434k
NCRR NIH HHS C06 RR018898NCRR NIH HHS C06-RR018898NHLBI NIH HHS HL121561NHLBI NIH HHS HL123160NHLBI NIH HHS HL77131NHLBI NIH HHS R01 HL077131NHLBI NIH HHS R01 HL123160NHLBI NIH HHS R21 HL121561NIDDK NIH HHS DK102325NIDDK NIH HHS DK104273NIDDK NIH HHS DK73608NIDDK NIH HHS R01 DK073608NIDDK NIH HHS R01 DK102325NIDDK NIH HHS U01 DK104273
6 · The paper itself

Abstract

backgroundLeft ventricular (LV) hypertrophy (LVH) plays an important role in hypertensive heart disease, and may be accompanied by myocardial autophagy. However, the pattern of autophagy during evolution of LVH is unclear. We hypothesized that autophagy activation indicates advancing cardiac LVH with tissue remodeling.

methodsTen domestic pigs with a 10-week unilateral renovascular hypertension (HTN) were classified as mild or moderate HTN (n = 5 each group) based on the degree of renal artery stenosis (above or below 75%). Seven normal pigs served as controls. Left ventricular remodeling, function, and microvascular density were assessed using multi-detector- and micro-computed tomography and histology. Markers of myocardial autophagic and endoplasmic reticulum (ER) stress-related unfolded protein response (UPR), apoptosis, and fibrosis were examined ex vivo.

resultsBoth HTN groups had increased myocyte cross-sectional area, but it was greater in moderate HTN, accompanied by elevated LV muscle-mass. Moderate, but not mild HTN, also showed impaired microvascular density and impaired myocardial perfusion. Autophagy mediators were unaltered in mild HTN but UPR markers were increased, while in moderate HTN they were all upregulated, whereas UPR markers were suppressed. Myocardial apoptosis and fibrosis were also greater in moderate HTN. Autophagic proteins were correlated with LVH and fibrosis.

conclusionsAutophagic activity is stimulated during the exacerbation of LVH, following a transient early increase in ER stress, and may be involved in the progression of cardiac remodeling in renovascular hypertensive heart disease.

Indexed as

AutophagyAnimalsCardiomegalyCell CountDisease Models, AnimalHypertension, RenovascularMultidetector Computed TomographyMyocytes, CardiacSwineVentricular Function, LeftX-Ray Microtomographyautophagyblood pressurehypertensionleft ventricular hypertrophyrenal artery stenosisrenin-angiotensin-aldosterone systemunfolded protein response.

Identifiers

PMID25904651
PMCPMC5863784
OpenAlexW1995711333

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.