ReviewJournal of neurointerventional surgery2016
From bench to bedside: utility of the rabbit elastase aneurysm model in preclinical studies of intracranial aneurysm treatment.
Review in Journal of neurointerventional surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- MRI Visibility and MR-DSA Concordance of the Nuvascular Harbor Intrasaccular Occlusion Device: A Preclinical Study.Brain sciences · 2026Article
- Towards the Intravascular Delivery of 3D-printed Leached SMP for Endovascular Treatment of Intracranial Aneurysm.Annals of biomedical engineering · 2025Article
- Measuring artery diameter in rabbit angiograms for neurovascular disease modeling applications and device testing.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Flow Diversion for Endovascular Treatment of Intracranial Aneurysms: Past, Present, and Future Directions.Journal of clinical medicine · 2024Review
- Demonstration of 1000 fps High-Speed Angiography (HSA) in Pre-Clinical In-vivo Rabbit Aneurysm Models During Flow-Diverter Treatment.Proceedings of SPIE--the International Society for Optical Engineering · 2024Article
- High wall shear stress-dependent podosome formation in a novel murine model of intracranial aneurysm.Frontiers in stroke · 2024Article
- Spatially resolved transcriptomics for evaluation of intracranial vessels in a rabbit model: Proof of concept.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke.Journal of visualized experiments : JoVE · 2023Article
- Article
- Photosensitive Hydrogel-Based Embolic Agent Treatment of Wide-Necked Aneurysms: Preliminary Animal Results.Gels (Basel, Switzerland) · 2022Article
- Rabbit Elastase Aneurysm Model Mimics the Recurrence Rate of Human Intracranial Aneurysms following Platinum Coil Embolization.AJNR. American journal of neuroradiology · 2022Article
- Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review.Journal of cellular physiology · 2022Review
- Evaluation of Outcome Prediction of Flow Diversion for Intracranial Aneurysms.AJNR. American journal of neuroradiology · 2021Article
- Endogenous animal models of intracranial aneurysm development: a review.Neurosurgical review · 2021Review
- Endothelialized silicone aneurysm models for in vitro evaluation of flow diverters.Journal of neurointerventional surgery · 2021Article
- Comparative bioinformatics analysis between proteomes of rabbit aneurysm model and human intracranial aneurysm with label-free quantitative proteomics.CNS neuroscience & therapeutics · 2021Article
- Preclinical safety and efficacy evaluation of the Pipeline Vantage Embolization Device with Shield Technology.Journal of neurointerventional surgery · 2020Article
- The development and understanding of intracranial aneurysm based on rabbit model.Neuroradiology · 2020Review
- Comparison of Aneurysm Patency and Mural Inflammation in an Arterial Rabbit Sidewall and Bifurcation Aneurysm Model under Consideration of Different Wall Conditions.Brain sciences · 2020Article
- Custom tissue engineered aneurysm models with varying neck size and height for early stage in vitro testing of flow diverters.Journal of materials science. Materials in medicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Preclinical studies are important in helping practitioners and device developers improve techniques and tools for endovascular treatment of intracranial aneurysms. Thus an understanding of the major animal models used in such studies is important. The New Zealand rabbit elastase induced arterial aneurysm of the common carotid artery is one of the most commonly used models in testing the safety and efficacy of new endovascular devices. In this review we discuss: (1) the various techniques used to create the aneurysm, (2) complications of aneurysm creation, (3) natural history of the arterial aneurysm, (4) histopathologic and hemodynamic features of the aneurysm, (5) devices tested using this model, and (6) weaknesses of the model. We demonstrate how preclinical studies using this model are applied in the treatment of intracranial aneurysms in humans. The model has similar hemodynamic, morphological, and histologic characteristics to human aneurysms, and demonstrates similar healing responses to coiling as human aneurysms. Despite these strengths, however, the model does have many weaknesses, including the fact that the model does not emulate the complex inflammatory processes affecting growing and ruptured aneurysms. Furthermore, the extracranial location of the model affects its ability to be used in preclinical safety assessments of new devices. We conclude that the rabbit elastase model has characteristics that make it a simple and effective model for preclinical studies on the endovascular treatment of intracranial aneurysms, but further work is needed to develop aneurysm models that simulate the histopathologic and morphologic characteristics of growing and ruptured aneurysms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.