Observational studyThe Journal of infectious diseases2015
High Viral Load and Respiratory Failure in Adults Hospitalized for Respiratory Syncytial Virus Infections.
Observational study in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04414059 (Complications Risk Factors in Patients Hospitalized for COVID-19 Infection), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Complications Risk Factors in Patients Hospitalized for COVID-19 Infection: Role of Proteins Electrophoresis
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The Epidemiology of Healthcare-Acquired Respiratory Syncytial Virus Infection Among Hospitalised Paediatric Patients: a Systematic Review and Meta-Analysis.Influenza and other respiratory viruses · 2025Pooled it
- Reduced Respiratory Syncytial Virus Load, Symptoms, and Infections: A Human Challenge Trial of MVA-BN-RSV Vaccine.The Journal of infectious diseases · 2023Trial
- Prevention of Respiratory Syncytial Virus Infection in Healthy Adults by a Single Immunization of Ad26.RSV.preF in a Human Challenge Study.The Journal of infectious diseases · 2022Trial
- Viral load is strongly associated with length of stay in adults hospitalised with viral acute respiratory illness.The Journal of infection · 2016Trial
- A Study on Clinical Features of Respiratory Syncytial Virus in Acute Respiratory Tract Infection in Elderly Hospitalized Patients in Winter.Canadian respiratory journal · 2026Article
- Mathematical modelling of the heterogeneity of disease progression and treatment outcomes in patients with COVID-19.Frontiers in microbiology · 2025Article
- Review
- Unravelling the acute respiratory infection landscape: virus type, viral load, health status and coinfection do matter.Frontiers in cellular and infection microbiology · 2024Article
- Systematic Literature Review of Risk Factors for Poor Outcomes Among Adults With Respiratory Syncytial Virus Infection in High-Income Countries.Open forum infectious diseases · 2023Article
- RSV-associated hospitalization in adults in the USA: A retrospective chart review investigating burden, management strategies, and outcomes.Health science reports · 2022Article
- Application of MRT-qPCR for pathogen detection of lower respiratory tract infection.American journal of translational research · 2022Article
- SARS-CoV-2 viral load at presentation to hospital is independently associated with the risk of death.The Journal of infection · 2021Article
- Early events in hepatitis B infection: the role of inoculum dose.Proceedings. Biological sciences · 2021Article
- Immunosuppression for hyperinflammation in COVID-19: a double-edged sword?Lancet (London, England) · 2020Article
- Severe Illnesses Associated With Outbreaks of Respiratory Syncytial Virus and Influenza in Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Common cold in Team Finland during 2018 Winter Olympic Games (PyeongChang): epidemiology, diagnosis including molecular point-of-care testing (POCT) and treatment.British journal of sports medicine · 2019Observational
- Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2019Article
- The rate of viral transfer between upper and lower respiratory tracts determines RSV illness duration.Journal of mathematical biology · 2019Article
- Risk of mortality associated with respiratory syncytial virus and influenza infection in adults.BMC infectious diseases · 2017Article
- Respiratory Syncytial Virus and Other Noninfluenza Respiratory Viruses in Older Adults.Infectious disease clinics of North America · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 ± 1.47; day 3-4, 7.28 ± 1.41; day 5-8, 6.66 ± 1.87 log10 copies/mL). RNA concentration was independently associated with risk of complications and respiratory insufficiency (adjusted odds ratio 1.40 per log10 copies/mL increase, 95% confidence interval, 1.03-1.90; P = .034). Our data indicate the need and provide a basis for clinical research on antiviral therapy in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.