Evidence map›Paper›PMID 25904591›Full record

ArticleJournal of the American Heart Association2015

Trends in myocardial infarction secondary prevention: The National Health and Nutrition Examination Surveys (NHANES), 1999-2012.

Nilay S Shah, Mark D Huffman, Hongyan Ning, Donald M Lloyd-Jones

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Secondary Prevention After Myocardial Infarction in the United States.Journal of the American College of Cardiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nilay S ShahDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (N.S.S., M.D.H., H.N., D.M.L.J.) Department of Medicine, Stanford University School of Medicine, Stanford, CA (N.S.S.).
Mark D HuffmanDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (N.S.S., M.D.H., H.N., D.M.L.J.) Department of Medicine-Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL (M.D.H., D.M.L.J.).
Hongyan NingDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (N.S.S., M.D.H., H.N., D.M.L.J.).
Donald M Lloyd-JonesDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (N.S.S., M.D.H., H.N., D.M.L.J.) Department of Medicine-Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL (M.D.H., D.M.L.J.).
Northwestern University · USStanford University · US

Funding

Acute Coronary Syndrome Quality Improvement in Kerala (ACS QUIK)R00HL107749 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HUFFMAN, MARK D · 2014 to 2016
$744k
NHLBI NIH HHS 1 R00 HL107749NHLBI NIH HHS R00 HL107749
6 · The paper itself

Abstract

backgroundNationally representative data evaluating recent trends and future projections of vascular risk factor treatment and control rates in secondary prevention of ischemic heart disease are sparse. METHODS AND

resultsWe evaluated sex- and race-stratified cholesterol, blood pressure, and hemoglobin A1c levels and risk factor treatment and control rates in 1580 individuals who self-reported a history of myocardial infarction from The National Health and Nutrition Examination Surveys (NHANES) 1999 to 2012. We used weighted linear regression to estimate time trends and created forward linear projections to 2020. Participants were 30% to 41% women, 73% to 85% white, and had a mean age of 63 to 66 years. Cholesterol treatment rates increased and reached above 80% in men and women by 2011-2012, with significant increases in control rates (as then defined) in men to 85% in 2011-2012, with projections to reach 100% by 2020. Cholesterol treatment rates significantly increased in non-Hispanic whites and Hispanics. Statin use increased significantly to 73% of myocardial infarction survivors by 2011-2012, and aspirin use increased significantly but only to 28% by 2011-2012. There were no changes in blood pressure treatment or control rates by sex, and hypertension treatment increased only in non-Hispanic blacks. Projected hypertension control rates remained suboptimal.

conclusionsWhile temporal trends suggest improvements in cholesterol treatment, unchanged treatment and control of blood pressure and persistently low aspirin use represent missed opportunities. Urgent action is needed to improve secondary prevention rates projected by 2020 to reduce recurrent events in this high-risk group.

Indexed as

AgedAspirinBlood GlucoseFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaHypertensionMaleMiddle AgedMyocardial InfarctionNutrition SurveysRacial GroupsSecondary PreventionSex FactorsUnited StatesAspirinBlood GlucoseHydroxymethylglutaryl-CoA Reductase Inhibitorsmyocardial infarctionsecondary preventiontrends

Identifiers

PMID25904591
PMCPMC4579957
OpenAlexW2167850039

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.