ArticleOpen biology2015
Discovery of sea urchin NGFFFamide receptor unites a bilaterian neuropeptide family.
Article in Open biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Large-scale deorphanization ofeLife · 2024Article
- A Putative Role of Vasopressin/Oxytocin-Type Neuropeptide in Osmoregulation and Feeding Inhibition ofInternational journal of molecular sciences · 2023Article
- Somatostatin-type and allatostatin-C-type neuropeptides are paralogous and have opposing myoregulatory roles in an echinoderm.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nemertean, Brachiopod, and Phoronid Neuropeptidomics Reveals Ancestral Spiralian Signaling Systems.Molecular biology and evolution · 2021Article
- Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling.eLife · 2020Article
- Ancient role of vasopressin/oxytocin-type neuropeptides as regulators of feeding revealed in an echinoderm.BMC biology · 2019Article
- Neuropeptide precursors and neuropeptides in the sea cucumber Apostichopus japonicus: a genomic, transcriptomic and proteomic analysis.Scientific reports · 2019Article
- A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae ofFrontiers in zoology · 2019Article
- Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome.Scientific reports · 2018Article
- Evolution of neuropeptide signalling systems.The Journal of experimental biology · 2018Review
- Biochemical, Anatomical, and Pharmacological Characterization of Calcitonin-Type Neuropeptides in Starfish: Discovery of an Ancient Role as Muscle Relaxants.Frontiers in neuroscience · 2018Article
- Characterization of NGFFYamide Signaling in Starfish Reveals Roles in Regulation of Feeding Behavior and Locomotory Systems.Frontiers in endocrinology · 2018Article
- Neuropeptidergic Systems in Pluteus Larvae of the Sea UrchinFrontiers in endocrinology · 2018Article
- Pedal peptide/orcokinin-type neuropeptide signaling in a deuterostome: The anatomy and pharmacology of starfish myorelaxant peptide in Asterias rubens.The Journal of comparative neurology · 2017Article
- The evolution of neuropeptide signalling: insights from echinoderms.Briefings in functional genomics · 2017Review
- Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms.Open biology · 2017Article
- Functional Characterization of Paralogous Gonadotropin-Releasing Hormone-Type and Corazonin-Type Neuropeptides in an Echinoderm.Frontiers in endocrinology · 2017Article
- Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways.Scientific reports · 2016Article
- Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution.Open biology · 2016Article
- Localization of Neuropeptide Gene Expression in Larvae of an Echinoderm, the StarfishFrontiers in neuroscience · 2016Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptides are ancient regulators of physiology and behaviour, but reconstruction of neuropeptide evolution is often difficult owing to lack of sequence conservation. Here, we report that the receptor for the neuropeptide NGFFFamide in the sea urchin Strongylocentrotus purpuratus (phylum Echinodermata) is an orthologue of vertebrate neuropeptide-S (NPS) receptors and crustacean cardioactive peptide (CCAP) receptors. Importantly, this has facilitated reconstruction of the evolution of two bilaterian neuropeptide signalling systems. Genes encoding the precursor of a vasopressin/oxytocin-type neuropeptide and its receptor duplicated in a common ancestor of the Bilateria. One copy of the precursor retained ancestral features, as seen in highly conserved vasopressin/oxytocin-neurophysin-type precursors. The other copy diverged, but this took different courses in protostomes and deuterostomes. In protostomes, the occurrence of a disulfide bridge in neuropeptide product(s) of the precursor was retained, as in CCAP, but with loss of the neurophysin domain. In deuterostomes, we see the opposite scenario-the neuropeptides lost the disulfide bridge, and neurophysin was retained (as in the NGFFFamide precursor) but was subsequently lost in vertebrate NPS precursors. Thus, the sea urchin NGFFFamide precursor and receptor are 'missing links' in the evolutionary history of neuropeptides that control ecdysis in arthropods (CCAP) and regulate anxiety in humans (NPS).
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