ArticleJournal of the Royal Society, Interface2015
Coordination of contractility, adhesion and flow in migrating Physarum amoebae.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Cytoskeletal prestress homeostasis is a biological principle that governs living cell structure and function.Mechanobiology in medicine · 2026Review
- Mycelial dynamics in arbuscular mycorrhizal fungi.The New phytologist · 2026Review
- Emergence of multiple collective motility modes in a physical model of cell chains.NPJ systems biology and applications · 2025Article
- The evolution and diversity of actin-dependent cell migration.Molecular biology of the cell · 2023Review
- Behavioural changes in slime moulds over time.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Vein fate determined by flow-based but time-delayed integration of network architecture.eLife · 2023Article
- Tracking Mechanical Stress and Cell Migration with Inexpensive Polymer Thin-Film Sensors.Advanced materials interfaces · 2023Article
- Article
- Self-organization in amoeboid motility.Frontiers in cell and developmental biology · 2022Review
- Origins of eukaryotic excitability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Adaptive behaviour and learning in slime moulds: the role of oscillations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Encoding memory in tube diameter hierarchy of living flow network.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Substrate and cell fusion influence on slime mold network dynamics.Scientific reports · 2021Article
- Immersed Methods for Fluid-Structure Interaction.Annual review of fluid mechanics · 2020Article
- Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment.Journal of the Royal Society, Interface · 2019Article
- Article
- Article
- Oscillatory fluid flow drives scaling of contraction wave with system size.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Fluid flows shaping organism morphology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Cytoplasmic Flow and Mixing Due to Deformation of Motile Cells.Biophysical journal · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
This work examines the relationship between spatio-temporal coordination of intracellular flow and traction stress and the speed of amoeboid locomotion of microplasmodia of Physarum polycephalum. We simultaneously perform particle image velocimetry and traction stress microscopy to measure the velocity of cytoplasmic flow and the stresses applied to the substrate by migrating Physarum microamoebae. In parallel, we develop a mathematical model of a motile cell which includes forces from the viscous cytosol, a poro-elastic, contractile cytoskeleton and adhesive interactions with the substrate. Our experiments show that flow and traction stress exhibit back-to-front-directed waves with a distinct phase difference. The model demonstrates that the direction and speed of locomotion are determined by this coordination between contraction, flow and adhesion. Using the model, we identify forms of coordination that generate model predictions consistent with experiments. We demonstrate that this coordination produces near optimal migration speed and is insensitive to heterogeneity in substrate adhesiveness. While it is generally thought that amoeboid motility is robust to changes in extracellular geometry and the nature of extracellular adhesion, our results demonstrate that coordination of adhesive forces is essential to producing robust migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.