Evidence map›Paper›PMID 25904361›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015

The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration.

Mark W Logue, Ananda B Amstadter, Dewleen G Baker, Laramie Duncan, Karestan C Koenen, Israel Liberzon, Mark W Miller, Rajendra A Morey, Caroline M Nievergelt, Kerry J Ressler and 5 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 9 pooled it
35.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 9 syntheses or guidelines pooled it, 160 citations in OpenAlex.

  1. Pooled it
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  10. Trial
  11. Review
  12. Article
  13. Post-traumatic stress disorder.Nature reviews. Disease primers · 2026
    Review
  14. Article
  15. Article
  16. Article
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  19. Post-traumatic stress disorder: evolving conceptualization and evidence, and future research directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Article
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 1 country.

Mark W Logue1] Research, VA Boston Healthcare System, Boston, MA, USA [2] Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA [3] Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Ananda B AmstadterVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Dewleen G Baker1] Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA [2] VA San Diego Healthcare System, VA Center of Excellence for Stress and Mental Health (CESAMH), La Jolla, CA, USA.
Laramie Duncan1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [2] Analytic and Translational Genetics Unit, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA [3] Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Israel Liberzon1] Department of Psychiatry, University of Michigan, Ann Arbor, MI [2] Veterans Affairs Ann Arbor Health System, Ann Arbor, MI, USA.ORCID 000000024990556X
Mark W Miller1] National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA [2] Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.ORCID 0000000163938563
Rajendra A Morey1] Duke-UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA [2] Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA [3] Mental Illness Research Education and Clinical Center for Post Deployment Mental Health, Durham VA Medical Center, Durham, NC, USA.
Caroline M Nievergelt1] Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA [2] VA San Diego Healthcare System, VA Center of Excellence for Stress and Mental Health (CESAMH), La Jolla, CA, USA.
Kerry J Ressler1] Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA [2] Center for Behavioral Neuroscience, Yerkes National Primate Research Center, Atlanta, GA, USA [3] Howard Hughes Medical Institute, Bethesda, MD, USA.
Alicia K SmithDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Jordan W Smoller1] Center of Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA [2] Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA [3] Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Murray B SteinDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Jennifer A SumnerDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Monica Uddin1] Carl R Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA [2] Department of Psychology, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Broad Institute · USHarvard University · USUniversity of California San Diego · USBoston University · USDuke University · USEmory University · USHoward Hughes Medical Institute · USUniversity of Illinois Urbana-Champaign · USUniversity of Michigan · USVA Boston Healthcare System · USVA San Diego Healthcare System · USVirginia Commonwealth University · US

Funding

Psychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Genomic Predictors of Combat Stress Vulnerability and ResilienceR01MH093500 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M · 2011 to 2013
$2.7M
Epigenetic and Biobehavioral Determinants of Preterm Birth in Black WomenR01MD009064 · NIMHD · EMORY UNIVERSITY · PI DUNLOP, ANNE LANG, SMITH, ALICIA K · 2014 to 2018
$1.9M
Stress-induced Drinking in OEF/OIF Veterans: The Role of Combat History and PTSDR01AA020179 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI AMSTADTER, ANANDA B · 2010 to 2014
$1.6M
Epigenetic Biomarkers of Early Psychotropic Medication ExposureRC1MH088609 · NIMH · EMORY UNIVERSITY · PI BRENNAN, PATRICIA A, SMITH, ALICIA K · 2009 to 2010
$982k
Research and Mentoring on Integrating Psychiatric Genetics and NeuroscienceK24MH094614 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SMOLLER, JORDAN W · 2012 to 2016
$925k
NUCLEAR CAPTURE FOR CELL-TYPE SPECIFIC EPIGENETIC ANALYSIS OF ADIPOCYTESR01DK100392 · NIDDK · UNIVERSITY OF GEORGIA · PI MEAGHER, RICHARD BRIAN, SMITH, ALICIA K · 2014 to 2015
$670k
Stress-induced drinking in Returning Soldiers: Genetic and Epigenetic MechanismsK02AA023239 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI AMSTADTER, ANANDA B · 2014 to 2018
$643k
Genetic & Environmental Risk Factors that Contribute to Childhood PsychopathologyK01MH085806 · NIMH · EMORY UNIVERSITY · PI SMITH, ALICIA K · 2010 to 2013
$522k
Analysis of RORA and other candidate genes in PTSDI01BX002150 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MILLER, MARK W · 2013 to 2015
–
BLRD VA I01 BX002150NIAAA NIH HHS K02 AA023239NIAAA NIH HHS R01 AA020179NIDDK NIH HHS DK100392NIMHD NIH HHS MD009064NIMH NIH HHS K24 MH094614NIMH NIH HHS MH085806NIMH NIH HHS MH088609NIMH NIH HHS R01 MH093500NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH111671
6 · The paper itself

Abstract

The development of posttraumatic stress disorder (PTSD) is influenced by genetic factors. Although there have been some replicated candidates, the identification of risk variants for PTSD has lagged behind genetic research of other psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Psychiatric genetics has moved beyond examination of specific candidate genes in favor of the genome-wide association study (GWAS) strategy of very large numbers of samples, which allows for the discovery of previously unsuspected genes and molecular pathways. The successes of genetic studies of schizophrenia and bipolar disorder have been aided by the formation of a large-scale GWAS consortium: the Psychiatric Genomics Consortium (PGC). In contrast, only a handful of GWAS of PTSD have appeared in the literature to date. Here we describe the formation of a group dedicated to large-scale study of PTSD genetics: the PGC-PTSD. The PGC-PTSD faces challenges related to the contingency on trauma exposure and the large degree of ancestral genetic diversity within and across participating studies. Using the PGC analysis pipeline supplemented by analyses tailored to address these challenges, we anticipate that our first large-scale GWAS of PTSD will comprise over 10 000 cases and 30 000 trauma-exposed controls. Following in the footsteps of our PGC forerunners, this collaboration-of a scope that is unprecedented in the field of traumatic stress-will lead the search for replicable genetic associations and new insights into the biological underpinnings of PTSD.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyCooperative BehaviorGenomicsHumansPsychiatric Status Rating ScalesStress Disorders, Post-Traumatic

Identifiers

PMID25904361
PMCPMC4538342
OpenAlexW2022871897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.