Trial reportJournal of neurology2015
PPNa-DBS for gait and balance disorders in Parkinson's disease: a double-blind, randomised study.
Trial report in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 5 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson's disease: a network meta-analysis of randomized controlled trials.Frontiers in aging neuroscience · 2025Pooled it
- Interventions for preventing falls in Parkinson's disease.The Cochrane database of systematic reviews · 2022Pooled it
- Comparison of the Efficacy of Deep Brain Stimulation in Different Targets in Improving Gait in Parkinson's Disease: A Systematic Review and Bayesian Network Meta-Analysis.Frontiers in human neuroscience · 2021Pooled it
- Pedunculopontine Nucleus Deep Brain Stimulation Improves Gait Disorder in Parkinson's Disease: A Systematic Review and Meta-analysis.Neurochemical research · 2020Pooled it
- Comparison of Efficacy of Deep Brain Stimulation of Different Targets in Parkinson's Disease: A Network Meta-Analysis.Frontiers in aging neuroscience · 2019Pooled it
- Structural-Functional Correlates of Response to Pedunculopontine Stimulation in a Randomized Clinical Trial for Axial Symptoms of Parkinson's Disease.Journal of Parkinson's disease · 2023Trial
- Stereological analysis of cholinergic neurons within bilateral pedunculopontine nuclei in health and when affected by Parkinson's disease.Brain pathology (Zurich, Switzerland) · 2025Article
- Patient, target, device, and program selection for DBS in Parkinson's disease: advancing toward precision care.NPJ Parkinson's disease · 2025Review
- The Effects of Deep Brain Stimulation on Balance in Parkinson's Disease as Measured Using Posturography-A Narrative Review.Brain sciences · 2025Review
- Modulating the cholinergic system-Novel targets for deep brain stimulation in Parkinson's disease.Journal of neurochemistry · 2025Review
- Glutamatergic Circuits in the Pedunculopontine Nucleus Modulate Multiple Motor Functions.Neuroscience bulletin · 2024Article
- Scientometric Research and Critical Analysis of Gait and Balance in Older Adults.Sensors (Basel, Switzerland) · 2024Review
- Unraveling the threads of stability: A review of the neurophysiology of postural control in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Substantia Nigra Pars Reticulata Projections to the Pedunculopontine Nucleus Modulate Dyskinesia.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Parkinson's disease updates: Addressing the pathophysiology, risk factors, genetics, diagnosis, along with the medical and surgical treatment.Annals of medicine and surgery (2012) · 2023Review
- Efficacy of Dual-Task Training in Patients with Parkinson's Disease: A Systematic Review with Meta-Analysis.Movement disorders clinical practice · 2023Review
- Postural Instability and Risk of Falls in Patients with Parkinson's Disease Treated with Deep Brain Stimulation: A Stabilometric Platform Study.Brain sciences · 2023Article
- Novel utilization of deep brain stimulation in the pedunculopontine nucleus with globus pallidus internus for treatment of childhood-onset dystonia.Frontiers in human neuroscience · 2023Article
- Novel targets in deep brain stimulation for movement disorders.Neurosurgical review · 2022Review
- Disentangling the PIGD classification for the prediction of cognitive impairment in de novo Parkinson's disease.Journal of neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gait and balance disorders are the major source of motor disabilities in advanced forms of Parkinson's disease (PD). Low-frequency stimulation of the pedunculopontine nucleus area (PPNa-DBS) has been recently proposed to treat these symptoms with variable clinical results. To further understand the effects of PPNa-DBS on resistant gait and balance disorders, we performed a randomised double-blind cross-over study in six PD patients. Evaluation included clinical assessment of parkinsonian disability, quality of life and neurophysiological recordings of gait. Evaluations were done 1 month before, 4 and 6 months after surgery with four double-blinded conditions assessed: with and without PPNa-DBS, with and without levodopa treatment. Four patients completed the study and two patients were excluded from the final analysis because of peri-operative adverse events (haematoma, infection). Clinically, the combination of PPNa-DBS and levodopa treatment produced a significant decrease of the freezing episodes. The frequency of falls also decreased in three out of four patients. From a neurophysiological point of view, PPNa-DBS significantly improved the anticipatory postural adjustments and double-stance duration, but not the length and speed of the first step. Interestingly, step length and speed improved after surgery without PPNa-DBS, suggesting that the lesioning effect of PPNa-DBS surgery alleviates parkinsonian akinesia. Quality of life was also significantly improved with PPNa-DBS. These results suggest that PPNa-DBS could improve gait and balance disorders in well-selected PD patients. However, this treatment may be riskier than others DBS surgeries in these patients with an advanced form of PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.