Evidence map›Paper›PMID 25904142›Full record

ArticleJournal of diabetes science and technology2015

GoCARB in the Context of an Artificial Pancreas.

Aristotelis Agianniotis, Marios Anthimopoulos, Elena Daskalaki, Aurélie Drapela, Christoph Stettler, Peter Diem, Stavroula Mougiakakou

Registry-linked trialAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02546063 (Carbohydrate Estimation Supported by the GoCARB System in Individuals With Type 1 Diabetes), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02546063 nacompletednot on this map

Carbohydrate Estimation Supported by the GoCARB System in Individuals With Type 1 Diabetes

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2015 to 2015Enrolled20ConditionsDiabetes Mellitus, Type 1, CarbohydratesArmsSmartphone App
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aristotelis AgianniotisDiabetes Technology Research Group, ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.
Marios AnthimopoulosDiabetes Technology Research Group, ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.
Elena DaskalakiDiabetes Technology Research Group, ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.
Aurélie DrapelaDiabetes Technology Research Group, ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland.
Christoph StettlerDepartment of Endocrinology, Diabetes & Clinical Nutrition, Bern University Hospital "Inselspital," Bern, Switzerland.
Peter DiemDepartment of Endocrinology, Diabetes & Clinical Nutrition, Bern University Hospital "Inselspital," Bern, Switzerland.
Stavroula MougiakakouDiabetes Technology Research Group, ARTORG Center for Biomedical Engineering Research, University of Bern, Switzerland Department of Endocrinology, Diabetes & Clinical Nutrition, Bern University Hospital "Inselspital," Bern, Switzerland stavroula.mougiakakou@artorg.unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn an artificial pancreas (AP), the meals are either manually announced or detected and their size estimated from the blood glucose level. Both methods have limitations, which result in suboptimal postprandial glucose control. The GoCARB system is designed to provide the carbohydrate content of meals and is presented within the AP framework.

methodThe combined use of GoCARB with a control algorithm is assessed in a series of 12 computer simulations. The simulations are defined according to the type of the control (open or closed loop), the use or not-use of GoCARB and the diabetics' skills in carbohydrate estimation.

resultsFor bad estimators without GoCARB, the percentage of the time spent in target range (70-180 mg/dl) during the postprandial period is 22.5% and 66.2% for open and closed loop, respectively. When the GoCARB is used, the corresponding percentages are 99.7% and 99.8%. In case of open loop, the time spent in severe hypoglycemic events (<50 mg/dl) is 33.6% without the GoCARB and is reduced to 0.0% when the GoCARB is used. In case of closed loop, the corresponding percentage is 1.4% without the GoCARB and is reduced to 0.0% with the GoCARB.

conclusionThe use of GoCARB improves the control of postprandial response and glucose profiles especially in the case of open loop. However, the most efficient regulation is achieved by the combined use of the control algorithm and the GoCARB.

Indexed as

AlgorithmsPancreas, ArtificialBlood GlucoseCell PhoneComputer SimulationDiabetes Mellitus, Type 1Dietary CarbohydratesHumansHyperglycemiaHypoglycemiaInsulin Infusion SystemsPostprandial PeriodBlood GlucoseDietary Carbohydratesartificial pancreascarbohydrate countingcomputer visioncontrol algorithmtype 1 diabetes

Identifiers

PMID25904142
PMCPMC4604547

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.