ArticleJournal of dental research2015
Different Brain Responses to Pain and Its Expectation in the Dental Chair.
Article in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Preemptive use of etodolac on tooth sensitivity after in-office bleaching: a randomized clinical trial.Journal of applied oral science : revista FOB · 2018Trial
- Is the Modified Dental Anxiety Scale (MDAS) a Single or Two Construct Measure? A Theoretical and Pragmatic Perspective.Dentistry journal · 2025Article
- Waiting for pain: effect of a mindfulness intervention during a wait situation on pain intensity.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Explainable fNIRS-based pain decoding under pharmacological conditions via deep transfer learning approach.Neurophotonics · 2024Article
- Artificial Intelligence-Driven Diagnostic Processes and Comprehensive Multimodal Models in Pain Medicine.Journal of personalized medicine · 2024Review
- Self-administered transcranial direct current stimulation treatment of knee osteoarthritis alters pain-related fNIRS connectivity networks.Neurophotonics · 2023Article
- Study Protocol of tDCS Based Pain Modulation in Head and Neck Cancer Patients Under Chemoradiation Therapy Condition: An fNIRS-EEG Study.Frontiers in molecular neuroscience · 2022Article
- Review
- Pain Management for Dental Medicine in 2021: Opioids, Coronavirus and Beyond.Journal of pain research · 2021Article
- Feasibility of a Real-Time Clinical Augmented Reality and Artificial Intelligence Framework for Pain Detection and Localization From the Brain.Journal of medical Internet research · 2019Article
- Brain Functional Changes before, during, and after Clinical Pain.Journal of dental research · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
A dental appointment commonly prompts fear of a painful experience, yet we have never fully understood how our brains react to the expectation of imminent tooth pain once in a dental chair. In our study, 21 patients with hypersensitive teeth were tested using nonpainful and painful stimuli in a clinical setting. Subjects were tested in a dental chair using functional near-infrared spectroscopy to measure cortical activity during a stepwise cold stimulation of a hypersensitive tooth, as well as nonpainful control stimulation on the same tooth. Patients' sensory-discriminative and emotional-cognitive cortical regions were studied through the transition of a neutral to a painful stimulation. In the putative somatosensory cortex contralateral to the stimulus, 2 well-defined hemodynamic peaks were detected in the homuncular orofacial region: the first peak during the nonpainful phase and a second peak after the pain threshold was reached. Moreover, in the upper-left and lower-right prefrontal cortices, there was a significant active hemodynamic response in only the first phase, before the pain. Subsequently, the same prefrontal cortical areas deactivated after a painful experience had been reached. Our study indicates for the first time that pain perception and expectation elicit different hemodynamic cortical responses in a dental clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.